9-环戊基嘌呤衍生物的合成与抗病毒活性
Synthesis and antiviral activities of 9-cyclopentylpurine derivatives.
作者信息
Kojima E, Ohta K, Miyawaki S, Date T, Machida M, Murakami K
机构信息
Biochemistry Section, Iwakuni Research Laboratory of Technology, Nippon Paper Industries Co. Ltd, Yamaguchi, Japan.
出版信息
Nucleic Acids Symp Ser. 1995(34):107-8.
PMID:8841575
Abstract
The synthesis and anti-RSV (Rouse Sarcoma Virus) activity of HMCA, (+/-)-9-(2-hydroxymethyl-cyclopenthyl)-adenine, and its derivatives are described. It has been demonstrated that trans-HMCA has greater anti-RSV activity in tissue culture than cis-HMCA.
摘要
描述了HMCA（(±)-9-(2-羟甲基-环戊基)-腺嘌呤）及其衍生物的合成与抗呼吸道合胞病毒（RSV）活性。已证明反式HMCA在组织培养中比顺式HMCA具有更强的抗RSV活性。
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