• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

9-环戊基嘌呤衍生物的合成与抗病毒活性

Synthesis and antiviral activities of 9-cyclopentylpurine derivatives.

作者信息

Kojima E, Ohta K, Miyawaki S, Date T, Machida M, Murakami K

机构信息

Biochemistry Section, Iwakuni Research Laboratory of Technology, Nippon Paper Industries Co. Ltd, Yamaguchi, Japan.

出版信息

Nucleic Acids Symp Ser. 1995(34):107-8.

PMID:8841575
Abstract

The synthesis and anti-RSV (Rouse Sarcoma Virus) activity of HMCA, (+/-)-9-(2-hydroxymethyl-cyclopenthyl)-adenine, and its derivatives are described. It has been demonstrated that trans-HMCA has greater anti-RSV activity in tissue culture than cis-HMCA.

摘要

描述了HMCA（(±)-9-(2-羟甲基-环戊基)-腺嘌呤）及其衍生物的合成与抗呼吸道合胞病毒（RSV）活性。已证明反式HMCA在组织培养中比顺式HMCA具有更强的抗RSV活性。

相似文献

1
Synthesis and antiviral activities of 9-cyclopentylpurine derivatives.9-环戊基嘌呤衍生物的合成与抗病毒活性
Nucleic Acids Symp Ser. 1995(34):107-8.
2
Synthesis and structure-activity relationships of 2',3'-dideoxypurine nucleosides as potential antiretroviral agents.2',3'-双脱氧嘌呤核苷作为潜在抗逆转录病毒药物的合成及其构效关系
Nucleic Acids Symp Ser. 1991(25):91-2.
3
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.9-[2-(膦酰甲氧基)乙基]腺嘌呤和(R)-9-[2-(膦酰甲氧基)丙基]腺嘌呤新型α-硼烷核苷酸类似物的合成、体外抗病毒评估及稳定性研究
J Med Chem. 2006 Dec 28;49(26):7799-806. doi: 10.1021/jm060030y.
4
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.N6-取代腺嘌呤和 2,6-二氨基嘌呤的 N9-[3-氟-2-(膦酸甲氧基)丙基]类似物的合成及抗病毒活性。
Bioorg Med Chem. 2011 Apr 1;19(7):2114-24. doi: 10.1016/j.bmc.2011.02.050. Epub 2011 Mar 4.
5
(R)-(-)- and (S)-(+)-Synadenol: synthesis, absolute configuration, and enantioselectivity of antiviral effect.（R）-（-）-和（S）-（+）-Synadenol：合成、绝对构型及抗病毒作用的对映选择性
J Med Chem. 1998 Dec 17;41(26):5257-64. doi: 10.1021/jm980323u.
6
Synthesis of purine bases having a di(hydroxymethyl)cyclopentenyl group by means of high-pressure reaction and their anti-HIV activity.通过高压反应合成具有二（羟甲基）环戊烯基的嘌呤碱及其抗HIV活性。
Nucleic Acids Symp Ser. 1991(25):5-6.
7
Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.9-(S)-(3-羟基-2-膦酰甲氧基丙基)腺嘌呤的烷氧基烷基衍生物对巨细胞病毒和正痘病毒的合成及抗病毒评价
J Med Chem. 2006 Mar 23;49(6):2010-5. doi: 10.1021/jm050473m.
8
A convenient approach to the synthesis of nucleic acid bases allenic derivatives, possessing anti-HIV activity.
Nucleic Acids Symp Ser. 1991(24):233.
9
Synthesis and biological evaluation of beta-D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines.
Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):605-9. doi: 10.1081/NCN-120021964.
10
Synthesis and antiviral properties of arabino and ribonucleosides of 1,3-dideazaadenine, 4-nitro-1,3-dideazapurine and diketopiperazine.1,3 - 二氮杂腺嘌呤、4 - 硝基 - 1,3 - 二氮杂嘌呤和二酮哌嗪的阿拉伯糖核苷及核糖核苷的合成与抗病毒特性
Nucleosides Nucleotides Nucleic Acids. 2004;23(12):1815-24. doi: 10.1081/NCN-200040614.