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Synthesis and biological evaluation of beta-D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines.

作者信息

Mathé Christophe, Lioux Thierry, Gosselin Gilles

机构信息

Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-Université Montpellier II, Montpellier, France.

出版信息

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):605-9. doi: 10.1081/NCN-120021964.

DOI:10.1081/NCN-120021964
PMID:14565237
Abstract

Beta-D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines have been synthesized. The azido-tetrazolo tautomerism observed on such nucleoside analogues has been studied. The compounds were tested for their activity against HIV and HBV but they did not show significant antiviral effect.

摘要

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