基于锂化反应的6-氯-9-(β-D-呋喃核糖基)嘌呤的硅烷化和锡烷化反应
Lithiation-based silylation and stannylation of 6-chloro-9-(beta-D-ribofuranosyl)purine.
作者信息
Katoh K, Hayakawa H, Tanaka H, Kumamoto H, Miyasaka T
机构信息
School of Pharmaceutical Sciences, Showa University, Japan.
出版信息
Nucleic Acids Symp Ser. 1995(34):155-6.
PMID:8841599
Abstract
Reaction of the lithiated species of 9-(2,3,5-tris-O-tert-butyldimethylsilyl-beta-D-ribofuranosyl)-6-chloropu rine with Me3SiCl or Bu3SnCl was found to furnish the corresponding C-2 substituted product, as a result of silyl or stannyl migration from C-8 to C-2 position.
摘要
9-(2,3,5-三-O-叔丁基二甲基甲硅烷基-β-D-呋喃核糖基)-6-氯嘌呤的锂化物种与Me3SiCl或Bu3SnCl反应，结果发现由于硅烷基或锡烷基从C-8迁移至C-2位，生成了相应的C-2取代产物。
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