Kryzhanovskiĭ G N, Grafova V N, Danilova E I
Biull Eksp Biol Med. 1977 May;83(5):515-9.
Using tetanus toxin as a tool to disturb the inhibition, enhanced excitation generators were created in the anterior horns of lumbar segments of the left and right sides of albino rat spinal cord. The generators worked at different regimens: the "left-side" generator originating under conditions of a more prolonged toxin action, on being activated by trigger stimulation, produced first tonic and then intermittent activity or periodic spontaneous discharges; the "right-side" generator produced only tonic activity. After the inhibition of one of the generators by glycine the other continued working in its regimen. Activation of one of the generators was followed by inhibition of the effect of the other. In case of separate activation of one of the generators all pools of the spinal and supraspinal motor neurons reproduced the activity pattern of the generator working at that moment. Thus, the latter played the role of the hyperactive structure determining the system behaviour, i.e. the determinant. The evidence obtained is analyzed from the point of view of the general concept on the role of the determinant structures in the nervous system activity and the theory of generator mechanisms of the neuropathological syndromes characterized by the system hyperactivity.
利用破伤风毒素作为干扰抑制作用的工具，在白化大鼠脊髓左右两侧腰段前角中产生了增强的兴奋发生器。这些发生器以不同的方式工作：“左侧”发生器在毒素作用时间更长的条件下产生，在触发刺激激活时，首先产生强直性活动，然后是间歇性活动或周期性自发放电；“右侧”发生器仅产生强直性活动。在用甘氨酸抑制其中一个发生器后，另一个仍按其方式继续工作。激活其中一个发生器后，另一个发生器的效应会受到抑制。如果单独激活其中一个发生器，脊髓和脊髓上运动神经元的所有池都会重现当时工作的发生器的活动模式。因此，后者起到了决定系统行为的多动结构的作用，即决定因素。从关于决定因素结构在神经系统活动中的作用的一般概念以及以系统多动为特征的神经病理综合征的发生器机制理论的角度，对所获得的证据进行了分析。
