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Similarities and differences between the vascular endothelial growth factor (VEGF) splice variants.

作者信息

Neufeld G, Cohen T, Gitay-Goren H, Poltorak Z, Tessler S, Sharon R, Gengrinovitch S, Levi B Z

机构信息

Department of Biology, Technion, Israel Institute of Technology, Haifa, Israel.

出版信息

Cancer Metastasis Rev. 1996 Jun;15(2):153-8. doi: 10.1007/BF00437467.

DOI:10.1007/BF00437467
PMID:8842486
Abstract
摘要

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Similarities and differences between the vascular endothelial growth factor (VEGF) splice variants.血管内皮生长因子（VEGF）剪接变体之间的异同
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Endotoxins induce and interferon alpha suppresses vascular endothelial growth factor (VEGF) production in human peripheral blood mononuclear cells.内毒素可诱导人外周血单核细胞产生血管内皮生长因子（VEGF），而α干扰素则可抑制其产生。
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Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion.白细胞介素-1α通过诱导炎症细胞合成和分泌血管内皮生长因子（VEGF），经血管内皮生长因子受体-2（VEGFR-2）途径促进体内血管生成。
FASEB J. 2002 Sep;16(11):1471-3. doi: 10.1096/fj.02-0134fje. Epub 2002 Jul 18.
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VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma.血管内皮生长因子抑制性剪接变体VEGF165b在肾细胞癌中表达下调。
Cancer Res. 2002 Jul 15;62(14):4123-31.
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J Biol Chem. 2003 May 9;278(19):17164-9. doi: 10.1074/jbc.M212224200. Epub 2003 Feb 21.
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Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor.硫酸乙酰肝素及相关分子在成纤维细胞生长因子的隔离和生长促进活性中的作用。
Cancer Metastasis Rev. 1996 Jun;15(2):177-86. doi: 10.1007/BF00437470.
2
Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain.通过其7号外显子编码结构域结合VEGF165的肿瘤细胞上新型血管内皮生长因子（VEGF）受体的特性分析
J Biol Chem. 1996 Mar 8;271(10):5761-7. doi: 10.1074/jbc.271.10.5761.
3
Selective binding of VEGF121 to one of the three vascular endothelial growth factor receptors of vascular endothelial cells.
Biomolecules. 2023 Apr 20;13(4):702. doi: 10.3390/biom13040702.
4
VEGF-A -Induced Endothelial Cells Chemotactic Migration and Invasion Assays.VEGF-A诱导的内皮细胞趋化迁移和侵袭实验。
Methods Mol Biol. 2022;2475:205-214. doi: 10.1007/978-1-0716-2217-9_14.
5
Identification of Characteristic Autoantibodies Associated With Deficiency Pattern in Traditional Chinese Medicine of Rheumatoid Arthritis Using Protein Chips.运用蛋白质芯片技术鉴定类风湿关节炎中医虚证相关特征性自身抗体
Front Pharmacol. 2019 Jul 10;10:755. doi: 10.3389/fphar.2019.00755. eCollection 2019.
6
Arachidonic Acid Derived Lipid Mediators Influence Kaposi's Sarcoma-Associated Herpesvirus Infection and Pathogenesis.花生四烯酸衍生的脂质介质影响卡波西肉瘤相关疱疹病毒的感染和发病机制。
Front Microbiol. 2019 Mar 12;10:358. doi: 10.3389/fmicb.2019.00358. eCollection 2019.
7
Isoform 165 of vascular endothelial growth factor in collagen matrix improves ovine cryopreserved ovarian tissue revascularisation after xenotransplantation in mice.胶原蛋白基质中血管内皮生长因子的165亚型可改善绵羊冷冻保存的卵巢组织在小鼠异种移植后的血管再生。
Reprod Biol Endocrinol. 2015 Mar 7;13:12. doi: 10.1186/s12958-015-0015-2.
8
Multiple roles for VEGF in non-melanoma skin cancer: angiogenesis and beyond.血管内皮生长因子在非黑素瘤皮肤癌中的多种作用：血管生成及其他。
J Skin Cancer. 2012;2012:483439. doi: 10.1155/2012/483439. Epub 2012 Oct 17.
9
VEGF-A and VEGF-B mRNA expression in gastro-oesophageal cancers.血管内皮生长因子 A 和 B 在胃食管癌症中的 mRNA 表达。
Clin Transl Oncol. 2013 Apr;15(4):313-20. doi: 10.1007/s12094-012-0923-y. Epub 2012 Aug 8.
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Knockdown of aberrantly expressed nuclear localized decorin attenuates tumour angiogenesis related mediators in oral cancer progression model in vitro.在体外口腔癌进展模型中，敲低异常表达的核定位核心蛋白聚糖可减弱肿瘤血管生成相关介质。
Head Neck Oncol. 2012 Jun 8;4:11. doi: 10.1186/1758-3284-4-11.
血管内皮生长因子121（VEGF121）与血管内皮细胞的三种血管内皮生长因子受体之一的选择性结合。
J Biol Chem. 1996 Mar 8;271(10):5519-23. doi: 10.1074/jbc.271.10.5519.
4
Differential expression of vascular endothelial growth factor (vascular permeability factor) forms in rat tissues.大鼠组织中血管内皮生长因子（血管通透因子）不同形式的差异表达。
Growth Factors. 1995;12(1):11-5. doi: 10.3109/08977199509003209.
5
Identification and localization of alternately spliced mRNAs for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines.人子宫中血管内皮生长因子可变剪接mRNA的鉴定与定位及子宫内膜癌细胞系中的雌激素调节
Biol Reprod. 1993 May;48(5):1120-8. doi: 10.1095/biolreprod48.5.1120.
6
Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells.血管内皮生长因子的表达不会促进转化，但赋予中国仓鼠卵巢细胞在体内的生长优势。
J Clin Invest. 1993 Jan;91(1):160-70. doi: 10.1172/JCI116166.
7
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract.血管通透因子（血管内皮生长因子）及其受体在胃肠道腺癌中的表达
Cancer Res. 1993 Oct 1;53(19):4727-35.
8
Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas.血管通透性因子（血管内皮生长因子）及其受体在肾癌和膀胱癌中的表达增加。
Am J Pathol. 1993 Nov;143(5):1255-62.
9
Heparin modulates the interaction of VEGF165 with soluble and cell associated flk-1 receptors.肝素调节血管内皮生长因子165（VEGF165）与可溶性及细胞相关的fms样酪氨酸激酶-1（flk-1）受体之间的相互作用。
J Biol Chem. 1994 Apr 29;269(17):12456-61.
10
The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.血管内皮生长因子（VEGF）亚型：在基底膜下细胞外基质中的差异沉积以及细胞外基质结合型VEGF的生物活性
Mol Biol Cell. 1993 Dec;4(12):1317-26. doi: 10.1091/mbc.4.12.1317.