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[X射线照射对子宫腺上皮细胞DNA合成的影响及其与有丝分裂周期各阶段的关系]

[Effect of x-irradiation on DNA-synthesis in uterine gland epithelium and the relationship of that effect to the phase of the mitotic cycle].

作者信息

Ogandzhanian E E, Mkrtchian S A

出版信息

Biull Eksp Biol Med. 1977 May;83(5):586-8.

PMID:884266
Abstract

The autoradiographic method with the use of thymidone-3H was applied to the study of X-irradiation influence on the DNA synthesis in the epithelium of the endometrial glands of ovariectomized mice stimulated with synestrol, and of the dependence of this action on the mitotic cycle phase. It appeared that in local irradiation of the uterus with a dose of 400 r reduction of the labeled nuclei index (LNI) in the cells of the endometrial glands differed and depended on the mitotic cycle phase of the majority of the cells.

摘要

运用含3H-胸腺嘧啶核苷的放射自显影法,研究了X射线对用炔雌醇刺激的去卵巢小鼠子宫内膜腺上皮细胞DNA合成的影响,以及这种作用对有丝分裂周期阶段的依赖性。结果表明,子宫局部照射400伦琴剂量时,子宫内膜腺细胞中标记核指数(LNI)的降低有所不同,并取决于大多数细胞的有丝分裂周期阶段。

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