大动脉炎与溃疡性结肠炎相关；这种关联中的遗传因素。

Takayasu's arteritis associated with ulcerative colitis; genetic factors in this association.

作者信息

Morita Y, Yamamura M, Suwaki K, Mima A, Ishizu T, Hirohata M, Kashihara N, Makino H, Ota Z

机构信息

Third Department of Internal Medicine, Okayama University Medical School.

出版信息

Intern Med. 1996 Jul;35(7):574-8. doi: 10.2169/internalmedicine.35.574.

DOI:10.2169/internalmedicine.35.574

PMID:8842766

Abstract

Both ulcerative colitis and Takayasu's arteritis are though to be organ-specific immune-mediated inflammatory diseases. We present the rare case of a 23-year-old woman with a 4-year history of ulcerative colitis who developed Takayasu's arteritis one month after giving birth. She was found to carry the human leukocyte antigens (HLA)-B52 and DR2, which were previously noted to be associated with these inflammatory conditions in the Japanese population. The pathogenic relevance of this haplotype to the concomitant development of these two conditions is discussed.

摘要

溃疡性结肠炎和大动脉炎都被认为是器官特异性免疫介导的炎症性疾病。我们报告了一例罕见病例，一名23岁女性，有4年溃疡性结肠炎病史，产后1个月发生了大动脉炎。她被发现携带人类白细胞抗原（HLA）-B52和DR2，此前在日本人群中发现这些抗原与这些炎症性疾病有关。本文讨论了这种单倍型与这两种疾病并发的致病相关性。