Bekhtereva E P
Biull Eksp Biol Med. 1977 Jun;83(6):741-2.
The effect of sygethin on anovulatory cycle was studied in mature female rats. Anovulation was experimentally induced in rats on the one hand by stress effect (keeping rats in crowded conditions), and on the other hand by removing one ovary (hemicastration). Sygethin therapy (10 mg/kg for 4-5 days) proved to restore normal ovulation. When higher sygethin doses were used, and when it was administered for longer periods (for 2 to 3 weeks) no such effect proved to ensue. The results of these experiments suggest that small doses of sygethin stimulated luteinizing hormone secretion.
研究了sygethin对成熟雌性大鼠无排卵周期的影响。一方面通过应激效应（将大鼠置于拥挤环境中），另一方面通过摘除一侧卵巢（半阉割）在大鼠中实验性诱导无排卵。Sygethin治疗（10毫克/千克，持续4 - 5天）被证明可恢复正常排卵。当使用更高剂量的sygethin以及当给药时间更长（2至3周）时，未证明有此效果。这些实验结果表明，小剂量的sygethin刺激促黄体生成素的分泌。
