Tsui S K, Chan P P, Cheuk C W, Liew C C, Waye M M, Fung K P, Lee C Y
Department of Biochemistry, Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Biochem Mol Biol Int. 1996 Jul;39(4):747-54. doi: 10.1080/15216549600201831.
A full-length cDNA clone encoding a zinc finger protein was isolated and sequenced. This full-length clone consists of 728 bp and has a predicted open reading frame (ORF) encoding 208 amino acids. The ORF of this polypeptide codes for the human cysteine-rich protein 2 (HCRP2) and has an amino acid sequence that is 92.8% identical to its rat homolog (RCRP2). HCRP2 was mapped to chromosome 14q32, which is a hot spot of translocation in tumor development, by fluorescent in situ hybridization (FISH).
分离并测序了一个编码锌指蛋白的全长cDNA克隆。这个全长克隆由728个碱基对组成，具有一个预测的开放阅读框（ORF），编码208个氨基酸。该多肽的开放阅读框编码人富含半胱氨酸蛋白2（HCRP2），其氨基酸序列与其大鼠同源物（RCRP2）的同源性为92.8%。通过荧光原位杂交（FISH）将HCRP2定位到染色体14q32，该区域是肿瘤发生过程中易位的热点。
