Borovicka J, Kreiss C, Asal K, Remy B, Mettraux C, Wells A, Read N W, Jansen J B, D'Amato M, Delaloye A B, Fried M, Schwizer W
Department of Gastroenterology, University Hospital, Lausanne, Switzerland.
Am J Physiol. 1996 Sep;271(3 Pt 1):G448-53. doi: 10.1152/ajpgi.1996.271.3.G448.
The role of endogenous cholecystokinin (CCK) in the regulation of gastric emptying remains controversial. We therefore studied the effect of the CCK-A receptor antagonist loxiglumide on gastric emptying of a high-caloric solid-liquid meal in humans. Gastric emptying was assessed in eight volunteers using intravenous loxiglumide or placebo in a randomized double-blind order. Subjects were studied by a dual-headed gamma camera after ingestion of a pancake (570 kcal) labeled with 99mTc-sulfur colloid and 500 ml 10% glucose containing 111In-diethylenetriamine pentaacetic acid. Plasma CCK was measured by a specific radioimmunoassay. Loxiglumide markedly accelerated gastric emptying of both phases of the meal. The lag period was shortened by 26% (P < 0.03); the area under the emptying curve and half-emptying time of solid emptying were lowered by 19 and 24% (P < 0.02) and of liquid emptying by 18 and 24% (P < 0.04), respectively. Plasma CCK levels were higher during infusion of loxiglumide compared with placebo (P < 0.02). These data demonstrate that post-prandially released CCK is a major regulator of gastric emptying of physiological meals containing both solid and liquid components.
内源性胆囊收缩素（CCK）在胃排空调节中的作用仍存在争议。因此，我们研究了CCK-A受体拮抗剂洛西肽胺对人体高热量固体-液体餐胃排空的影响。采用随机双盲顺序，对8名志愿者静脉注射洛西肽胺或安慰剂，评估胃排空情况。在摄入用99mTc-硫胶体标记的煎饼（570千卡）和含有111In-二乙三胺五乙酸的500毫升10%葡萄糖后，用双头γ相机对受试者进行研究。通过特异性放射免疫测定法测量血浆CCK。洛西肽胺显著加速了餐食两个阶段的胃排空。延迟期缩短了26%（P<0.03）；固体排空的排空曲线下面积和半排空时间分别降低了19%和24%（P<0.02），液体排空的排空曲线下面积和半排空时间分别降低了18%和24%（P<0.04）。与安慰剂相比，输注洛西肽胺期间血浆CCK水平更高（P<0.02）。这些数据表明，餐后释放的CCK是含有固体和液体成分的生理性餐食胃排空的主要调节因子。
