δ9-四氢大麻酚在不同环境温度下对大鼠体温及脑胺浓度的影响。
The effect of delta9-tetrahydrocannabinol on body temperature and brain amine concentrations in the rat at differnt ambient temperatures.
作者信息
Fennessy M R, Taylor D A
出版信息
Br J Pharmacol. 1977 May;60(1):65-71. doi: 10.1111/j.1476-5381.1977.tb16748.x.
Abstract
- Rats were injected intravenously with 2 mg/kg (-)-trans-delta9-tetrahydrocannabinol (delta9-THC) at ambient temperatures of 4 degrees, 21 degrees, 31 degrees and 37 degrees C. 2. The general behavior exhibited by rats treated with delta9-THC was similar at all four ambient temperatures. 3. Body temperatures were recorded continuously before and after drug administration. At 4 degrees and 21 degrees C, delta9-THC caused hypothermia whereas no change in body temperature occurred at 31 degrees and 37 degrees C. 4. The concentrations in the whole brain of noradrenaline (NA), dopamine, 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were determined spectrophotofluorimetrically 1 h after drug administration. At 4 degrees C delta9-THC caused an increase of 5-HT, at 21 degrees C an increase of 5-HIAA, at 21 degrees C an increase of 5-HIAA AND A decrease of NA, and at 37 degrees C an increase of 5-HT and 5-HIAA. 5. At all ambient temperatures, delta9-THC increased the brain levels of 5-HT and/or 5-HIAA. A correlation between the delta9-THC-induced hypothermic response and the possible alteration of brain 5-HT metabolism cannot be excluded.
摘要
- 在4℃、21℃、31℃和37℃的环境温度下，给大鼠静脉注射2毫克/千克的（-）-反式-δ9-四氢大麻酚（δ9-THC）。2. 在所有四个环境温度下，用δ9-THC处理的大鼠表现出的一般行为相似。3. 在给药前后连续记录体温。在4℃和21℃时，δ9-THC导致体温过低，而在31℃和37℃时体温没有变化。4. 在给药1小时后，用分光光度荧光法测定全脑中去甲肾上腺素（NA）、多巴胺、5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）的浓度。在4℃时，δ9-THC导致5-HT增加，在21℃时5-HIAA增加，在21℃时5-HIAA增加且NA减少，在37℃时5-HT和5-HIAA增加。5. 在所有环境温度下，δ9-THC均增加了大脑中5-HT和/或5-HIAA的水平。不能排除δ9-THC诱导的体温过低反应与大脑5-HT代谢可能改变之间的相关性。
相似文献
1
The effect of delta9-tetrahydrocannabinol on body temperature and brain amine concentrations in the rat at differnt ambient temperatures.δ9-四氢大麻酚在不同环境温度下对大鼠体温及脑胺浓度的影响。
Br J Pharmacol. 1977 May;60(1):65-71. doi: 10.1111/j.1476-5381.1977.tb16748.x.
2
Biphasic nature of the effects of delta9-tetrahydrocannabinol on body temperature and brain amines of the rat.9-四氢大麻酚对大鼠体温和脑胺类物质影响的双相性质
Eur J Pharmacol. 1977 Nov 15;46(2):93-9. doi: 10.1016/0014-2999(77)90244-8.
3
Relationship between body temperature and brain monoamines during the development of tolerance to delat9-tetrahydrocannabinol in the rat.大鼠对Δ9-四氢大麻酚产生耐受性过程中体温与脑单胺之间的关系。
Psychopharmacology (Berl). 1978 Apr 11;56(3):279-85. doi: 10.1007/BF00432850.
4
Antagonism of the effects on thermoregulation of delta9-tetrahydrocannabinol by clomipramine in the rat.氯米帕明对大鼠体内δ9-四氢大麻酚体温调节作用的拮抗作用。
Br J Pharmacol. 1978 Jun;63(2):267-73. doi: 10.1111/j.1476-5381.1978.tb09756.x.
5
Time-course of the effects of chronic delta 9-tetrahydrocannabinol on behaviour, body temperature, brain amines and withdrawal-like behaviour in the rat.慢性Δ⁹-四氢大麻酚对大鼠行为、体温、脑胺及戒断样行为影响的时间进程。
J Pharm Pharmacol. 1982 Apr;34(4):240-5. doi: 10.1111/j.2042-7158.1982.tb04235.x.
6
Effects of delta9-tetrahydrocannabinol on the rates of oxygen consumption of mice.9-四氢大麻酚对小鼠耗氧率的影响。
Br J Pharmacol. 1977 Aug;60(4):559-68. doi: 10.1111/j.1476-5381.1977.tb07535.x.
7
The effects of (-)-delta9-tetrahydrocannabinol on reserpine-induced hypothermia in rats.(-)-δ9-四氢大麻酚对利血平诱导的大鼠体温过低的影响。
Br J Pharmacol. 1973 Oct;49(2):243-52. doi: 10.1111/j.1476-5381.1973.tb08369.x.
8
Modulation of delta9-tetrahydrocannabinol-induced hypothermia by fluoxetine in the rat.氟西汀对大鼠中δ9-四氢大麻酚诱导的体温过低的调节作用
Br J Pharmacol. 1998 Aug;124(7):1419-24. doi: 10.1038/sj.bjp.0701980.
9
The effect of (-)-trans-delta 9-tetrahydrocannabinol on regional brain levels and subcellular distribution of monoamines in the rat.(-)-反式-δ9-四氢大麻酚对大鼠脑区单胺水平及亚细胞分布的影响。
Clin Exp Pharmacol Physiol. 1979 Sep-Oct;6(5):541-8. doi: 10.1111/j.1440-1681.1979.tb00037.x.
10
Effects of coadministration of cannabinoids and morphine on nociceptive behaviour, brain monoamines and HPA axis activity in a rat model of persistent pain.大麻素与吗啡联合给药对持续性疼痛大鼠模型伤害性感受行为、脑单胺类物质及下丘脑-垂体-肾上腺（HPA）轴活性的影响
Eur J Neurosci. 2004 Feb;19(3):678-86. doi: 10.1111/j.0953-816x.2004.03177.x.
引用本文的文献
1
Synthetic cannabinoids found in "spice" products alter body temperature and cardiovascular parameters in conscious male rats.在“香料”产品中发现的合成大麻素会改变清醒雄性大鼠的体温和心血管参数。
Drug Alcohol Depend. 2017 Oct 1;179:387-394. doi: 10.1016/j.drugalcdep.2017.07.029. Epub 2017 Aug 18.
2
Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatment-a Systematic Review.大麻素呕吐综合征：诊断、病理生理学及治疗——一项系统综述
J Med Toxicol. 2017 Mar;13(1):71-87. doi: 10.1007/s13181-016-0595-z. Epub 2016 Dec 20.
3
Cannabinoid-Induced Hyperemesis: A Conundrum-From Clinical Recognition to Basic Science Mechanisms.大麻素引起的呕吐：从临床识别到基础科学机制的难题
Pharmaceuticals (Basel). 2010 Jul 7;3(7):2163-2177. doi: 10.3390/ph3072163.
4
Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats.慢性给予 THC 可预防间歇性青少年 MDMA 给药的行为影响，并减弱 MDMA 诱导的大鼠发热和神经毒性。
Neuropharmacology. 2011 Dec;61(8):1183-92. doi: 10.1016/j.neuropharm.2011.07.002. Epub 2011 Jul 13.
5
Effects of opioids, cannabinoids, and vanilloids on body temperature.阿片类药物、大麻素类药物和香草酸类药物对体温的影响。
Front Biosci (Schol Ed). 2011 Jun 1;3(3):822-45. doi: 10.2741/190.
6
Endogenous cannabinoids induce fever through the activation of CB1 receptors.内源性大麻素通过激活 CB1 受体引起发热。
Br J Pharmacol. 2009 Aug;157(8):1494-501. doi: 10.1111/j.1476-5381.2009.00312.x.
7
delta 9-Tetrahydrocannabinol reduces brain regional histamine concentrations.9-四氢大麻酚降低脑区组胺浓度。
Br J Pharmacol. 1983 Mar;78(3):452-4. doi: 10.1111/j.1476-5381.1983.tb08804.x.
8
Attenuation of delta 9-tetrahydrocannabinol-induced withdrawal-like behaviour by delta 9-tetrahydrocannabinol.9-四氢大麻酚对9-四氢大麻酚诱导的戒断样行为的减弱作用。
Psychopharmacology (Berl). 1981;73(1):97-8. doi: 10.1007/BF00431112.
9
The mechanism of action of delta 9-tetrahydrocannabinol on body temperature in mice.δ9-四氢大麻酚对小鼠体温的作用机制。
Psychopharmacology (Berl). 1980;69(3):299-305. doi: 10.1007/BF00433100.
10
Withdrawal-like behaviour induced by inhibitors of biogenic amine reuptake in rats treated chronically with delta 9-tetrahydrocannabinol.在长期接受δ9-四氢大麻酚治疗的大鼠中，生物胺再摄取抑制剂诱导的戒断样行为
Psychopharmacology (Berl). 1980;68(3):261-7. doi: 10.1007/BF00428113.
本文引用的文献
1
CHANGES IN TEMPERATURE PRODUCED BY MICRO-INJECTIONS OF AMINES INTO THE ANTERIOR HYPOTHALAMUS OF CATS.向猫的下丘脑前部微量注射胺类物质所产生的温度变化。
J Physiol. 1965 Mar;177(2):239-45. doi: 10.1113/jphysiol.1965.sp007589.
2
EFFECTS ON TEMPERATURE OF AMINES INJECTED INTO THE CEREBRAL VENTRICLES. A NEW CONCEPT OF TEMPERATURE REGULATION.注入脑室的胺类对体温的影响。体温调节的新概念。
J Physiol. 1964 Sep;173(2):226-31. doi: 10.1113/jphysiol.1964.sp007454.
3
A NEW CONCEPT OF TEMPERATURE REGULATION BY AMINES IN THE HYPOTHALAMUS.下丘脑胺类物质调节体温的新概念。
Nature. 1963 Dec 28;200:1325. doi: 10.1038/2001325a0.
4
A fluorimetric method for the determination of dopamine (3-hydroxytyramine).一种测定多巴胺（3-羟基酪胺）的荧光分析法。
Acta Physiol Scand. 1958 Dec 15;44(3-4):293-8. doi: 10.1111/j.1748-1716.1958.tb01628.x.
5
The effect of exposure to heat and cold upon rat brain catecholamine and 5-hydroxytryptamine levels.冷热暴露对大鼠脑内儿茶酚胺和5-羟色胺水平的影响。
Can J Physiol Pharmacol. 1967 Jul;45(4):733-43. doi: 10.1139/y67-086.
6
Effect of environmental temperature on the turnover of noradrenaline in hypothalamus and other areas of rat brain.环境温度对大鼠下丘脑及其他脑区去甲肾上腺素周转的影响。
J Physiol. 1969 Jul;203(1):199-210. doi: 10.1113/jphysiol.1969.sp008859.
7
1-delta9-tetrahydrocannabinol: neurochemical and behavioral effects in the mouse.1-δ9-四氢大麻酚：对小鼠的神经化学和行为影响
Science. 1969 Mar 28;163(3874):1464-7. doi: 10.1126/science.163.3874.1464.
8
Brain amines and temperature regulation.脑胺与体温调节。
Pharmacology. 1968;1(6):329-44. doi: 10.1159/000135983.
9
The effect of delta-1-tetrahydrocannabinol on serotonin metabolism in the rat brain.δ-1-四氢大麻酚对大鼠脑内5-羟色胺代谢的影响。
Life Sci I. 1971 Apr 15;10(8):425-36. doi: 10.1016/0024-3205(71)90107-x.
10
Effect of an extract of cannabis and of some cannabinols on catecholamine metabolism in rat brain and heart.大麻提取物及某些大麻酚对大鼠脑和心脏儿茶酚胺代谢的影响。
Agents Actions. 1970 Mar;1(3):136-43. doi: 10.1007/BF01982400.
Zotero 插件