Losa García J E, Mateos Rodríguez F, Jiménez López A, Pérez Arellano J L
Servicio de Medicina Interna II, Hospital, Universitario de Salamanca, Spain.
J Investig Allergol Clin Immunol. 1996 Jul-Aug;6(4):222-31.
Classically, cyclosporin A has been reported to exert its immunomodulatory action through its effect on T lymphocytes by inhibiting the synthesis of interleukin 2. However, the inhibition of T-lymphocyte activation does not suitably account for all the effects observed following cyclosporin A administration. It is possible that some of them could be due to the action of cyclosporin A on other cells, among which are mononuclear phagocytes. This article offers a detailed review of the consequences of the interaction of cyclosporin A on the capacities (surface antigen expression and production of inflammatory mediators), functions (chemotaxis, phagocytosis, intracellular destruction and cytotoxicity) and actions (antimicrobial defense, antitumor defense and immune cooperation) of these cells. The general conclusion is that the capacities, functions and actions of the macrophages related to non-specific defense are more resistant to cyclosporin A than those related to immunoregulation.
传统上，据报道环孢素A通过抑制白细胞介素2的合成对T淋巴细胞发挥免疫调节作用。然而，T淋巴细胞激活的抑制并不能完全解释环孢素A给药后观察到的所有效应。其中一些效应可能归因于环孢素A对其他细胞的作用，单核吞噬细胞就是其中之一。本文详细综述了环孢素A与这些细胞的能力（表面抗原表达和炎性介质产生）、功能（趋化性、吞噬作用、细胞内破坏和细胞毒性）及作用（抗菌防御、抗肿瘤防御和免疫协作）相互作用的后果。总体结论是，与非特异性防御相关的巨噬细胞的能力、功能和作用比与免疫调节相关者对环孢素A更具抗性。
