Thorat S P, Thatte U M, Pai N, Dahanukar S A
Department of Pharmacology, Seth G.S. Medical College, Bombay, India.
Q J Med. 1994 May;87(5):311-4.
Cyclosporin is an immunosuppressant that acts by selectively inhibiting the activation of T lymphocytes. Its effects on monocytes and neutrophils are not well explored. We investigated the in vitro effects of cyclosporin on these cells, harvested from venous blood from nine healthy, non-smoking volunteers. In vitro incubation of monocytes with increasing concentrations of cyclosporin (5, 25 and 625 micrograms) depressed their phagocytosis by 22%, 32% and 49%, respectively, compared to the control values. The intracellular killing capacity of monocytes decreased by 26%, 31% and 43% with these doses, and neutrophil phagocytosis was depressed in a similar manner (16%, 30% and 40%). Patients receiving cyclosporin are susceptible to infections, and inhibition of these phagocytic cells by cyclosporin may be partly responsible for this. Neutrophil chemotaxis is reduced in patients with impaired renal function. Treating these patients with cyclosporin may in addition suppress the phagocytic function of these cells.
环孢素是一种免疫抑制剂，其作用机制是选择性抑制T淋巴细胞的活化。它对单核细胞和中性粒细胞的影响尚未得到充分研究。我们研究了环孢素对从9名健康、不吸烟志愿者静脉血中采集的这些细胞的体外作用。与对照值相比，用浓度不断增加的环孢素（5、25和625微克）对单核细胞进行体外孵育，其吞噬作用分别降低了22%、32%和49%。这些剂量使单核细胞的细胞内杀伤能力分别降低了26%、31%和43%，中性粒细胞的吞噬作用也以类似方式受到抑制（分别为16%、30%和40%）。接受环孢素治疗的患者易受感染，环孢素对这些吞噬细胞的抑制作用可能是造成这一情况的部分原因。肾功能受损患者的中性粒细胞趋化性降低。用环孢素治疗这些患者可能还会抑制这些细胞的吞噬功能。
