Dohil M, Prendiville J S
British Columbia's Children's Hospital, Vancouver, Canada.
Pediatr Dermatol. 1996 Jul-Aug;13(4):310-2. doi: 10.1111/j.1525-1470.1996.tb01247.x.
Our purpose was to determine if oral cimetidine, a histamine-receptor antagonist, might be of benefit in the treatment of extensive molluscum contagiosum in children. We present 13 pediatric patients in whom conventional treatment modalities for molluscum contagiosum were unsuccessful or difficult to apply. They were treated with a two-month course of oral cimetidine 40 mg/kg/day. All but three children who completed treatment experienced clearance of all lesions. These children had no new lesions but had persistence of several lesions. One child did not take the drug and did not clear. No adverse effects were observed. We conclude that oral cimetidine may be of benefit in the management of widespread or facial molluscum contagiosum in immunocompetent children.
我们的目的是确定组胺受体拮抗剂西咪替丁口服给药对治疗儿童泛发性传染性软疣是否有益。我们报告了13例儿科患者，他们采用常规方法治疗传染性软疣均未成功或难以实施。这些患者接受了为期两个月的口服西咪替丁治疗，剂量为40mg/kg/天。除3名完成治疗的儿童仍有几处病损残留外，其他患儿的所有病损均已清除。有一名儿童未服用该药，病损未清除。未观察到不良反应。我们得出结论，口服西咪替丁对免疫功能正常的儿童广泛或面部传染性软疣的治疗可能有益。
