Franco I
Section of Pediatric Urology, Department of Urology, New York Medical College, Valhalla, New York, USA.
J Urol. 2000 Sep;164(3 Pt 2):1074-5. doi: 10.1097/00005392-200009020-00038.
It is believed that most warts are self-limiting and generally require little or no treatment. When numerous or almost complete infestation of the perineum, genital area and groin is encountered it can be distressing and a difficult problem to treat in children. Multiple treatments with caustic agents are sometimes necessary, and treatment of perigenital warts may require use of anesthesia for multiple procedures. Cimetidine is a histamine receptor antagonist that has been used mainly to treat peptic ulcer disease. Recently it has been reported to be useful for the treatment of mucocutaneous candidiasis, herpes simplex, herpes zoster and verruca because of its immunomodulatory effects. Several studies have been published indicating its effectiveness in the treatment of warts.
We treated 4 children with extensive condylomata acuminata of the genital and perigenital areas with high doses of cimetidine in an attempt to eradicate the condyloma and avoid recurrence in 2 and as primary treatment in 2. All patients were treated with 30 to 40 mg./kg. cimetidine daily in 3 divided doses during a 3-month period.
All patients are free of condyloma at 24 months following treatment.
Our results show that cimetidine is useful for primary and adjunctive treatment of condyloma in young children. It also appears to be effective as first line therapy.
人们认为大多数疣是自限性的，通常很少或无需治疗。当会阴部、生殖器区域和腹股沟出现大量疣或几乎完全被感染时，这在儿童中可能会令人苦恼且难以治疗。有时需要用腐蚀性药物进行多次治疗，而治疗生殖器周围疣可能需要在多次治疗过程中使用麻醉。西咪替丁是一种组胺受体拮抗剂，主要用于治疗消化性溃疡疾病。最近有报道称，由于其免疫调节作用，它可用于治疗黏膜皮肤念珠菌病、单纯疱疹、带状疱疹和疣。已经发表了几项研究表明其在治疗疣方面的有效性。
我们用高剂量西咪替丁治疗了4例患有广泛生殖器及生殖器周围尖锐湿疣的儿童，试图根除疣体并避免2例复发以及作为另外2例的主要治疗方法。所有患者在3个月期间每天按30至40毫克/千克的剂量服用西咪替丁，分3次给药。
所有患者在治疗后24个月时疣体均已消失。
我们的结果表明，西咪替丁可用于幼儿尖锐湿疣的主要治疗和辅助治疗。它似乎也可作为一线治疗有效。
