Hazes B
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada.
Protein Sci. 1996 Aug;5(8):1490-501. doi: 10.1002/pro.5560050805.
Lectins form a class of proteins that have evolved a specialized carbohydrate-binding function. Based on amino acid sequence analysis, several lectin families have been described and a lectin domain, the (QxW)3 domain, was discussed recently based on 11 family members. In this paper, the (QxW)3 domain family is extended to 45 sequences, several of which have very low sequence identity with the previously known members of the family. A hidden Markov model was used to identify the most divergent members of the family. The expanded set of sequences gives us a more complete appreciation of the conserved features, and the lack thereof, in this lectin family. This, in turn, provides new insights in the structural and functional properties of the individual family members.
凝集素构成了一类已进化出特殊碳水化合物结合功能的蛋白质。基于氨基酸序列分析，已描述了几个凝集素家族，并且最近基于11个家族成员讨论了一个凝集素结构域，即（QxW）3结构域。在本文中，（QxW）3结构域家族扩展至45个序列，其中一些序列与该家族先前已知成员的序列同一性非常低。使用隐马尔可夫模型来识别该家族中差异最大的成员。扩展后的序列集使我们能更全面地了解这个凝集素家族中的保守特征以及缺乏的特征。反过来，这为各个家族成员的结构和功能特性提供了新的见解。
