Thibaut F, Cordier B, Kuhn J M
Department of Pschiatry, University of Rouen, France.
Psychoneuroendocrinology. 1996 May;21(4):411-9. doi: 10.1016/0306-4530(96)00004-2.
Six patients with severe paraphilia were treated with a long-acting gonadotrophin hormone releasing hormone analogue (GnRH-a). In five cases, the antiandrogen treatment ended their deviant sexual behaviour and markedly decreased their sexual fantasies and activities without significant side-effects. The beneficial effects of this treatment were maintained for 7 years in the patient where there was the longest follow-up. Two patients abruptly withdrew front their antiandrogen treatment at the end of the first and third year, respectively. Both relapsed within 8-10 weeks. One of them asked for resumption of antiandrogen treatment. In another case, in order to phase out antiandrogen treatment, testosterone (T) was added to the GnRH-a. In spite of normal T levels, and of resumption of normal sexual activities and deviant fantasies, deviant sexual behaviour did not return. A smoother phasing out of GnRH-a treatment is thought to be better than an abrupt withdrawal. However, the duration of antiandrogen treatment necessary to ensure a complete disappearance of deviant sexual behaviour remains uncertain, but is at least 4 years.
六名患有严重性偏好障碍的患者接受了长效促性腺激素释放激素类似物（GnRH-a）治疗。在五例患者中，抗雄激素治疗终止了他们的异常性行为，并显著减少了他们的性幻想和性活动，且无明显副作用。在随访时间最长的患者中，这种治疗的有益效果维持了7年。两名患者分别在第一年和第三年末突然停止抗雄激素治疗。两人均在8 - 10周内复发。其中一人要求恢复抗雄激素治疗。在另一例中，为了逐步停用抗雄激素治疗，在GnRH-a治疗中添加了睾酮（T）。尽管T水平正常，且恢复了正常的性活动和异常幻想，但异常性行为并未复发。逐步停用GnRH-a治疗被认为比突然停药更好。然而，确保异常性行为完全消失所需的抗雄激素治疗持续时间仍不确定，但至少为4年。
