Lubińska L
Brain Res. 1977 Jul 8;130(1):47-63. doi: 10.1016/0006-8993(77)90841-1.
A quantitative study of Wallerian degeneration was carried out on teased fibres. The breakdown into ovoids was used as the criterion of degeneration. The fragmentation of fibres begins near the point of nerve interrruption and spreads along the unbranched parts of axons at velocities correlated with fibre diameter and internodal length. The latent period, preceding the onset of fragmentation, lasts from 25.6 h in thin fibres to 45.0 h in the thickest fibres. The speed of the subsequent advance along the nerve varies correspondingly from 250 to 46 mm/day. In each internode the first ovoids appear in the middle, the ends of the internodal segment being initially spared. The spatiotemporal pattern of degeneration is consistent with the hypothesis that a neuronal trophic substance, normally ensuring the integrity of the axon, exerts transcellularly an inhibitory influence on the Schwann cell. This influence disappears when the amount or concentration of migrating trophic substances falls below a critical level in a stretch of axon. The overlying Schwann cells become mobile and exhibit intense metabolic activity, leading eventually to axonal disruption.
对分离出的神经纤维进行了沃勒变性的定量研究。分解为卵圆形被用作变性的标准。纤维的断裂始于神经中断点附近，并以与纤维直径和节间长度相关的速度沿着轴突的无分支部分扩展。断裂开始前的潜伏期，细纤维为25.6小时，最粗的纤维为45.0小时。随后沿神经推进的速度相应地从250毫米/天到46毫米/天不等。在每个节间，第一个卵圆形出现在中间，节间段的两端最初不受影响。变性的时空模式与以下假设一致：一种通常确保轴突完整性的神经营养物质通过跨细胞方式对施万细胞施加抑制性影响。当一段轴突中迁移的营养物质的数量或浓度降至临界水平以下时，这种影响就会消失。覆盖其上的施万细胞变得活跃并表现出强烈的代谢活动，最终导致轴突中断。
