Hatton M Q, McMurray A, Harnett A N
Beatson Oncology Centre, Western Infirmary, Glasgow, UK.
Clin Oncol (R Coll Radiol). 1995;7(4):268-9. doi: 10.1016/s0936-6555(05)80619-3.
We report an ulcerative skin reaction resulting from a subcutaneous infusion of isotonic methotrimeprazine and diamorphine. Skin reactions are a recognized side effect of this treatment, although they are reduced by the use of the isotonic formulation of methotrimeprazine. Frank ulceration has not been previously reported. It occurred in our patient despite low doses of diamorphine and methotrimeprazine, an isotonic formulation, and a short infusion time.
我们报告了一例因皮下输注等渗甲硫哒嗪和二醋吗啡而导致的溃疡性皮肤反应。皮肤反应是这种治疗公认的副作用，尽管使用甲硫哒嗪的等渗制剂可减少此类反应。此前尚未有明显溃疡的报告。尽管给予患者低剂量的二醋吗啡和甲硫哒嗪、使用等渗制剂且输注时间较短，但仍出现了溃疡。
