Ranson M, Thatcher N
CRC Department of Medical Oncology, University of Manchester, UK.
Anticancer Drugs. 1995 Oct;6 Suppl 5:53-63. doi: 10.1097/00001813-199510005-00006.
To improve the survival outlook for patients with small cell lung cancer a variety of chemotherapy strategies has been adopted. This review focuses on the evidence for schedule dependency, particularly with regard to etoposide, and reviews the use of alternating chemotherapy protocols and weekly regimens in small cell lung cancer treatment. Recent improvements in supportive care, with the use of haemopoietic growth factors and peripheral blood progenitor cells, have led to renewed interest in the concept of dose intensity. Preliminary results of dose intensification in small cell lung cancer are described and future prospects discussed.
为改善小细胞肺癌患者的生存前景，已采用了多种化疗策略。本综述着重于化疗方案依赖性的证据，尤其是关于依托泊苷的，并回顾了交替化疗方案和每周治疗方案在小细胞肺癌治疗中的应用。随着造血生长因子和外周血祖细胞的使用，支持治疗方面的近期进展引发了人们对剂量强度概念的新兴趣。本文描述了小细胞肺癌剂量强化的初步结果并讨论了未来前景。
