Nishimura N, Hongo M, Yamada M, Kawakami H, Ueno M, Okuno Y, Toyota T
Third Department of Internal Medicine, Toboku University School of Medicine, Sendai, Japan.
J Smooth Muscle Res. 1996 Apr;32(2):43-50. doi: 10.1540/jsmr.32.43.
To clarify the changes of esophageal motility along with age, we performed esophageal manometry on 47 healthy volunteers, and compared the values of four groups under 49 years old (n = 11), 50 to 59 (n = 15), 60 to 69 (n = 11), and over 70 years old (n = 10). Resting lower esophageal sphincter (LES) pressure in the group over 70 years old showed the tendency of decrease, but not statistically significant. Nadir LES pressure on swallow-induced relaxation was not statistically different among 4 groups. On esophageal body testing, percentage of non-conduction sequence in the group 60 to 69 and over 70 years old was statistically higher compared with that of the group under 49 years old (p < 0.05) but spared in some elderly subjects. Percentage of simultaneous contractions was not statistically different among 4 groups. Peristaltic contraction amplitude in the group over 70 years old was significantly lower than that of the group under 49 years old both at the level of 5 cm above (p < 0.01) and 10 cm above LES (p < 0.05). We speculate that the influence of aging on esophageal motility is the reduced transmission sequence of peristalsis and contractility of esophageal body. This alteration along with age may differ from the pathological condition of scleroderma or diffuse esophageal spasm.
为阐明食管动力随年龄的变化，我们对47名健康志愿者进行了食管测压，并比较了49岁以下（n = 11）、50至59岁（n = 15）、60至69岁（n = 11）和70岁以上（n = 10）四组的数值。70岁以上组的静息下食管括约肌（LES）压力呈下降趋势，但无统计学意义。四组在吞咽诱发松弛时的最低LES压力无统计学差异。在食管体部检测中，60至69岁组和70岁以上组的非传导序列百分比与49岁以下组相比有统计学意义的升高（p < 0.05），但部分老年受试者未出现。四组的同步收缩百分比无统计学差异。70岁以上组在LES上方5 cm水平（p < 0.01）和LES上方10 cm水平（p < 0.05）的蠕动收缩幅度均显著低于49岁以下组。我们推测衰老对食管动力的影响是食管体部蠕动的传导序列和收缩力降低。这种随年龄的改变可能不同于硬皮病或弥漫性食管痉挛的病理状态。
