Kuiper J W, van Kuijk C, Grashuis J L, Ederveen A G, Schütte H E
Department of Experimental Radiology, Erasmus University Medical School and University Hospital Dijkzigt, Rotterdam, Netherlands.
Osteoporos Int. 1996;6(1):25-30. doi: 10.1007/BF01626534.
Bone mineral measurements with quantitative computed tomography (QCT) and dual-energy X-ray absorptiometry (DXA) were compared with chemical analysis (ChA) to determine (1) the accuracy and (2) the influence of bone marrow fat. Total bone mass of 19 human femoral necks in vitro was determined with QCT and DXA before and after defatting. ChA consisted of defatting and decalcification of the femoral neck samples for determination of bone mineral mass (BmM) and amount of fat. The mean BmM was 4.49 g. Mean fat percentage was 37.2% (23.3%-48.5%). QCT, DXA and ChA before and after defatting were all highly correlated (r > 0.96, p < 0.0001). Before defatting the QCT values were on average 0.35 g less than BmM and the DXA values were on average 0.65 g less than BmM. After defatting, all bone mass values increased; QCT values were on average 0.30 g more than BmM and DXA values were 0.29 g less than BmM. It is concluded that bone mineral measurements of the femoral neck with QCT and DXA are highly correlated with the chemically determined bone mineral mass and that both techniques are influenced by the femoral fat content.
将定量计算机断层扫描（QCT）和双能X线吸收法（DXA）的骨矿物质测量结果与化学分析（ChA）进行比较，以确定（1）准确性和（2）骨髓脂肪的影响。在体外脱脂前后，用QCT和DXA测定了19例人股骨颈的总骨量。ChA包括对股骨颈样本进行脱脂和脱钙，以测定骨矿物质质量（BmM）和脂肪含量。平均BmM为4.49g。平均脂肪百分比为37.2%（23.3%-48.5%）。脱脂前后的QCT、DXA和ChA均高度相关（r>0.96，p<0.0001）。脱脂前，QCT值平均比BmM低0.35g，DXA值平均比BmM低0.65g。脱脂后，所有骨量值均增加；QCT值平均比BmM高0.30g，DXA值比BmM低0.29g。结论是，用QCT和DXA测量股骨颈的骨矿物质与化学测定的骨矿物质质量高度相关，并且这两种技术均受股骨脂肪含量的影响。
