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转基因和基因敲除小鼠在神经退行性疾病研究中的应用

Transgenic and knockout mice in the study of neurodegenerative diseases.

作者信息

Aguzzi A, Brandner S, Marino S, Steinbach J P

机构信息

Institute of Neuropathology, Department of Pathology, Zürich.

出版信息

J Mol Med (Berl). 1996 Mar;74(3):111-26. doi: 10.1007/BF01575443.

DOI:10.1007/BF01575443
PMID:8846161
Abstract

Accurate animal models are essential for detailed analysis of the mechanisms underlying human neurodegenerative diseases. In addition, they can offer useful paradigms for the development and evaluation of new therapeutic strategies. We review the most popular techniques for modification of the mammalian genome in vivo, and provide a critical evaluation of the available transgenic mouse models for several neurological conditions of humans, including prion diseases, human retroviral diseases, Alzheimer's disease, and motor neuron diseases.

摘要

精确的动物模型对于详细分析人类神经退行性疾病的潜在机制至关重要。此外，它们可为新治疗策略的开发和评估提供有用的范例。我们综述了体内修饰哺乳动物基因组的最常用技术，并对现有的针对人类多种神经疾病（包括朊病毒疾病、人类逆转录病毒疾病、阿尔茨海默病和运动神经元疾病）的转基因小鼠模型进行了批判性评估。

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Transgenic and knockout mice in the study of neurodegenerative diseases.转基因和基因敲除小鼠在神经退行性疾病研究中的应用
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2
Transgenic and knock-out mice: models of neurological disease.转基因和基因敲除小鼠：神经疾病模型
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