Schwartz B, Takamoto T, Lavin P
Tufts University School of Medicine, Boston, MA, USA.
Acta Ophthalmol Scand Suppl. 1995(215):41-53. doi: 10.1111/j.1600-0420.1995.tb00591.x.
The purpose of this study was to determine whether timolol drops compared to placebo drops had a significant effect on retinal vessel width in ocular hypertensives.
Thirty-seven ocular hypertensives were randomly assigned to receive placebo or 0.5% timolol drops to both eyes for 18 to 24 months in a double masked clinical trial. Measurements of ocular pressure and retinal vessel width by computerized image analysis from fundus photographs were made at about 3 month intervals for 18 to 24 months of follow-up.
None of the subjects developed visual field loss when tested with the Goldmann perimeter by kinetic and static means at six month intervals. Subjects treated with the placebo showed no change in ocular pressure and a significant decrease in retinal vessel width over time especially in the right eye. Subjects treated with timolol had an increase in retinal vessel width compared to the placebo group significant especially for the superior temporal vein. Multivariate analyses indicated that the increase of retinal vessel width was not associated mainly with the ocular pressure on treatment or decrease in ocular pressure on treatment.
Timolol treatment was associated with an increase of retinal vessel width. The effect of timolol appears to be related primarily to mechanisms other than the decrease in ocular pressure.
本研究旨在确定与安慰剂滴眼液相比，噻吗洛尔滴眼液对高眼压患者视网膜血管宽度是否有显著影响。
在一项双盲临床试验中，37名高眼压患者被随机分配接受安慰剂或0.5%噻吗洛尔滴眼液，双眼用药18至24个月。在18至24个月的随访期间，每隔约3个月通过眼底照片的计算机图像分析测量眼压和视网膜血管宽度。
当每隔6个月用动态和静态方法通过Goldmann视野计进行测试时，没有受试者出现视野缺损。接受安慰剂治疗的受试者眼压没有变化，随着时间的推移视网膜血管宽度显著减小，尤其是右眼。与安慰剂组相比，接受噻吗洛尔治疗的受试者视网膜血管宽度增加，尤其是颞上静脉，差异显著。多变量分析表明，视网膜血管宽度的增加主要与治疗时的眼压或治疗时眼压的降低无关。
噻吗洛尔治疗与视网膜血管宽度增加有关。噻吗洛尔的作用似乎主要与眼压降低以外的机制有关。
