Collignon N J, Collignon-Brach J D
Service of Ophthalmology, University of Liege, CHU-Domaine du Sart Tilman, Belgium.
Int Ophthalmol. 1997;21(4):199-203. doi: 10.1023/a:1005918922700.
To measure the effect of topical betaxolol 0.5% and timolol 0.5% on retinal vessels diameters by means of photographic enlargement.
Thirteen glaucomatous patients (primary open angle glaucoma (POAG) and ocular hypertensive (OH)) were treated twice daily with betaxolol 0.5% for one year. These same patients were subsequently treated with timolol 0.5% during the following year. Fundus photographs were taken with Canon camera 30 degree angle at baseline and two hours after instillation at 3, 6 and 12 months of treatment for each drug. The diameters of the superior and inferior temporal vessels (arteries and veins) were measured at one and two disc radii from the margin of the disc using photographic enlargement (x 66.7) of the right eye and were analysed under double masked fashion during the same session.
A significant increase of the mean arterial diameter (+ 7.4% p = 0.000 paired t) was found after 12 months of betaxolol treatment, while no persistent further difference (+ 1.3% NS) was found after 12 months of timolol treatment. No modification was found in venous diameter.
Betaxolol treatment is associated with a beneficial effect on retinal arteries width whereas Timolol does not yield the same amplitude of benefit.
通过照片放大测量0.5%倍他洛尔和0.5%噻吗洛尔局部用药对视网膜血管直径的影响。
13例青光眼患者（原发性开角型青光眼（POAG）和高眼压症（OH））每日两次使用0.5%倍他洛尔治疗一年。随后在接下来的一年中，这些患者使用0.5%噻吗洛尔进行治疗。在每种药物治疗的第3、6和12个月的基线期以及滴药后两小时，使用佳能相机以30度角拍摄眼底照片。使用右眼照片放大（x 66.7）在距视盘边缘一个和两个视盘半径处测量颞上和颞下血管（动脉和静脉）的直径，并在同一会诊期间以双盲方式进行分析。
倍他洛尔治疗12个月后，平均动脉直径显著增加（+7.4%，p = 0.000，配对t检验），而噻吗洛尔治疗12个月后未发现持续的进一步差异（+1.3%，无统计学意义）。静脉直径未发现改变。
倍他洛尔治疗对视网膜动脉宽度有有益影响，而噻吗洛尔未产生相同程度的益处。
