• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Role of surface IgM and IgD in the functional differentiation of human B lymphocytes: effect of papain treatment.

作者信息

Dosch H M, Kwong S, Tsui F, Zimmerman B, Gelfand E W

出版信息

J Immunol. 1979 Aug;123(2):557-60.

PMID:88476
Abstract

Short-term treatment of normal human B lymphocytes with low concentrations of papain resulted in selective and reversible removal of sIgD determinants, whereas HLA and Ia-like antigens, sIgM as well as receptors for E, C3, and FcIgG were unaffected. When studied for their capacity to generate antigen-specific direct PFC, papain-treated (delta-) B cells were highly sensitive to inactivation by even low concentrations of antigen. In addition, these cells were impaired in their ability to cooperate normally with T-helper cells or their humoral product(s).

摘要

相似文献

1
Role of surface IgM and IgD in the functional differentiation of human B lymphocytes: effect of papain treatment.
J Immunol. 1979 Aug;123(2):557-60.
2
Effects of neonatal anti-delta antibody treatment on the murine immune system. I. Suppression of development of surface IgD+ B cells and expansion of a surface IgM+ IgD- B lymphocyte population.新生鼠抗δ抗体治疗对小鼠免疫系统的影响。I. 表面IgD+B细胞发育的抑制及表面IgM+IgD-B淋巴细胞群体的扩增。
J Immunol. 1983 Aug;131(2):593-600.
3
The expression of surface IgD on B cells responsive to thymus-independent and thymus-dependent antigens and its requirement for B-cell triggering.对非胸腺依赖性抗原和胸腺依赖性抗原产生反应的B细胞表面IgD的表达及其对B细胞触发的需求。
Immunology. 1983 Feb;48(2):393-400.
4
Efficiency of antigen presentation after antigen targeting to surface IgD, IgM, MHC, Fc gamma RII, and B220 molecules on murine splenic B cells.抗原靶向小鼠脾脏B细胞表面的IgD、IgM、MHC、FcγRII和B220分子后抗原呈递的效率。
J Immunol. 1989 Jul 1;143(1):59-65.
5
Role of surface immunoglobulin in B lymphocyte activation.表面免疫球蛋白在B淋巴细胞激活中的作用。
Fed Proc. 1984 Aug;43(11):2624-32.
6
The relationship between surface immunoglobulin isotype and immune function of murine B lymphocytes. IV. Role of IgD-bearing cells in the propagation of immunologic memory.小鼠B淋巴细胞表面免疫球蛋白同种型与免疫功能的关系。IV. 含IgD细胞在免疫记忆增殖中的作用。
J Immunol. 1979 Aug;123(2):925-30.
7
The selective role of membrane IgG in the antigen-induced inhibition of human in vitro antibody synthesis.膜免疫球蛋白在抗原诱导的人体外抗体合成抑制中的选择性作用。
J Immunol. 1982 Jan;128(1):398-401.
8
Human peripheral blood B cell subpopulations: surface IgD+ cells respond to pokeweed mitogen with plasma cell differentiation.人类外周血B细胞亚群：表面IgD+细胞对商陆丝裂原产生反应并分化为浆细胞。
Clin Exp Immunol. 1986 Apr;64(1):150-7.
9
Anti-IgM but not anti-IgD antibodies inhibit cell division of normal human mature B cells.抗IgM抗体而非抗IgD抗体可抑制正常人成熟B细胞的细胞分裂。
J Immunol. 1992 Jan 1;148(1):29-34.
10
Cell surface immunoglobulin. XIX. Susceptibility of IgD and IgM on murine splenocytes to cleavage by papain.细胞表面免疫球蛋白。十九。小鼠脾细胞上IgD和IgM对木瓜蛋白酶裂解的敏感性。
J Immunol. 1976 Nov;117(5 Pt 1):1579-83.

引用本文的文献

1
Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging.分泌型IgM缺乏会改变视网膜格局，加剧与衰老相关的神经退行性变。
Immun Ageing. 2025 Feb 24;22(1):9. doi: 10.1186/s12979-025-00502-2.
2
Augmentation of in vitro humoral immune responses in the mouse by an antibody to IgD.抗IgD抗体增强小鼠体外体液免疫反应。
J Exp Med. 1980 Sep 1;152(3):493-506. doi: 10.1084/jem.152.3.493.
3
Study of proteolytic removal of Fab delta and Fe delta determinants of lymphocyte membrane IgD using a direct rosette assay.
利用直接玫瑰花结试验对淋巴细胞膜IgD的Fabδ和Feδ决定簇进行蛋白水解去除的研究。
Immunology. 1981 Sep;44(1):89-95.