Hamamoto K, Ohno T, Ogawa H
Third Department of Internal Medicine, Japanese Red Cross Society Wakayama Medical Center, Japan.
Rinsho Ketsueki. 1996 Apr;37(4):362-5.
A 54-year-old woman was diagnosed as having refractory anemia (RA) with CREST syndrome (incomplete type). She showed Raynaud's phenomenon, sclerodactyly and telangiectasia, but not calcinosis and esophageal dysmotility. Laboratory findings revealed anemia and thrombocytopenia, and myelodysplasia, abnormal karyotype of 47, XX, +8 in bone marrow cells. Antinuclear and centromere antibody was positive. Treatment with prednisolone was not successful. After prednisolone was tapered, she was given 20 mg/body metenolone orally, which led to hematological improvement, and after 6 months of therapy, abnormal karyotype of 47, XX, +8 disappeared.
一名54岁女性被诊断为患有伴有CREST综合征（不完全型）的难治性贫血（RA）。她表现出雷诺现象、指（趾）硬皮病和毛细血管扩张，但无钙质沉着和食管运动障碍。实验室检查发现贫血、血小板减少以及骨髓发育异常，骨髓细胞染色体核型为47, XX, +8异常。抗核抗体和着丝粒抗体呈阳性。泼尼松龙治疗未成功。泼尼松龙逐渐减量后，给予她口服美替诺龙20mg/体，这使血液学指标得到改善，治疗6个月后，47, XX, +8的异常核型消失。
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