Snyder S, Coodley E L, Durham B C, Pennock R S
Circulation. 1977 Sep;56(3):359-62. doi: 10.1161/01.cir.56.3.359.
Serum glycoprotein levels were compared in two groups of age- and sex-matched patients, 15 with coronary artery disease and 14 normal controls. While total glycoprotein levels were increased in the coronary group, significantly higher levels were found in only five of 16 glycoproteins--C3c haptoglobin, GC-globulin, alpha1-acid glycoprotein, and C3 activator--with no change in 10 other glycoproteins and significant decrease in transferrin. This study demonstrates what appears to be a glycoprotein profile in coronary artery disease and reviews possible interactions of glycoproteins with known risk factors in atherogenesis.
在两组年龄和性别匹配的患者中比较了血清糖蛋白水平，其中15例患有冠状动脉疾病，14例为正常对照。虽然冠状动脉疾病组的总糖蛋白水平升高，但在16种糖蛋白中只有5种——C3c、触珠蛋白、GC球蛋白、α1-酸性糖蛋白和C3激活剂——的水平显著更高，其他10种糖蛋白没有变化，转铁蛋白水平显著降低。这项研究证明了冠状动脉疾病中似乎存在的一种糖蛋白谱，并综述了糖蛋白与动脉粥样硬化形成中已知危险因素可能的相互作用。
