Tsuda T, Chi H, Liang Y, Rogaeva E A, Sherrington R, Levesque G, Ikeda M, Rogaev E I, Pollen D, Freedman M
Department of Medicine, Centre for Research in Neurodegenerative Diseases, University of Toronto, Canada.
Neurosci Lett. 1995 Dec 8;201(2):188-90. doi: 10.1016/0304-3940(95)12170-6.
The possibility of an interaction of multiple genes has been speculated in pathogenesis of Alzheimer's disease (AD). Because we have recently cloned a novel gene S182 bearing five different missense mutations which segregate with early-onset familial AD, we sought the frequency of these mutations in familial and sporadic late-onset AD to clarify the incidence of these mutations in the disease. The current study showed lack of these mutations in 118 independent subjects affected with late-onset Alzheimer's disease.
