Arolfo M P, Tinari R J, Ramírez O A
Departamento de Farmacología, Universidad Nacional de Córdoba, Argentina.
Physiol Behav. 1996 Jan;59(1):209-12. doi: 10.1016/0031-9384(95)02022-5.
The learning capacity of rats with an inborn high performance (HP) and low performance (LP) in an avoidance shuttle box paradigm, was evaluated in the Morris water maze. Escape latencies evaluated in HP and LP rats indicate that acquisition and retention of spatial information were not different from control animals. When a free swim trial was carried out, all groups showed a significant preference towards the target quadrant. Our results suggest that the altered hippocampal physiology described in HP and LP rats does not influence the performance of a spatial tasks such as the Morris water maze.
在穿梭箱范式中具有先天高性能（HP）和低性能（LP）的大鼠的学习能力，在莫里斯水迷宫中进行了评估。对HP和LP大鼠评估的逃避潜伏期表明，空间信息的获取和保持与对照动物没有差异。当进行自由游泳试验时，所有组对目标象限均表现出显著偏好。我们的结果表明，HP和LP大鼠中描述的海马生理改变并不影响诸如莫里斯水迷宫之类的空间任务的表现。
