• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

血清中氯丙嗪的气相色谱分析方法改进

Improved gas chromatographic analysis of chlorpromazine in blood serum.

作者信息

Davis C M, Meyer C J, Fenimore D C

出版信息

Clin Chim Acta. 1977 Jul 1;78(1):71-7. doi: 10.1016/0009-8981(77)90338-2.

DOI:10.1016/0009-8981(77)90338-2
PMID:884850
Abstract

Reliable determinations of chlorpromazine levels in blood serum samples obtained from patients were accomplished by electron capture gas chromatography. By using modifications of the procedure to insure stability of the sample, minimal losses during sample preparation and gas chromatography, and by selecting appropriate operating parameters of the electron capture detector, excellent agreement was obtained in replicate analyses with a limit of sensitivity of 1 ng/ml in 1 ml of plasma.

摘要

通过电子捕获气相色谱法可对从患者身上采集的血清样本中的氯丙嗪水平进行可靠测定。通过对该程序进行改进以确保样本的稳定性、样本制备和气相色谱过程中的最小损失,并选择电子捕获检测器的适当操作参数,在重复分析中获得了极佳的一致性,血浆中1毫升的检测灵敏度极限为1纳克/毫升。

相似文献

1
Improved gas chromatographic analysis of chlorpromazine in blood serum.血清中氯丙嗪的气相色谱分析方法改进
Clin Chim Acta. 1977 Jul 1;78(1):71-7. doi: 10.1016/0009-8981(77)90338-2.
2
Gas-chromatographic analysis for chlorpromazine and some of its metabolites in human serum, with use of a nitrogen detector.使用氮检测器对人血清中的氯丙嗪及其某些代谢物进行气相色谱分析。
Clin Chem. 1979 Jul;25(7):1211-5.
3
Measurement of plasma and erythrocyte chlorpromazine and N-monodesmethylchlorpromazine levels by gas chromatography with a nitrogen sensitive detector.采用带氮敏感检测器的气相色谱法测定血浆和红细胞中的氯丙嗪及N-去甲基氯丙嗪水平。
Acta Pharmacol Toxicol (Copenh). 1978 Apr;42(4):264-70. doi: 10.1111/j.1600-0773.1978.tb02199.x.
4
Determination of therapeutic and toxic concentrations of doxepin and loxapine using gas-liquid chromatography with a nitrogen-sensitive detector, and gas chromatography-mass spectrometry of loxapine.使用带有氮敏感检测器的气液色谱法测定多塞平和洛沙平的治疗浓度和中毒浓度,并对洛沙平进行气相色谱-质谱分析。
J Chromatogr. 1979 Dec 1;164(4):457-70. doi: 10.1016/s0378-4347(00)81548-0.
5
Promazine. A major plasma metabolite of chlorpromazine in a population of chronic schizophrenics.丙嗪。慢性精神分裂症患者群体中氯丙嗪的主要血浆代谢物。
Drug Metab Dispos. 1986 Mar-Apr;14(2):263-6.
6
Gas chromatographic--mass spectrometric procedure for the quantitation of chlorpromazine in plasma and its comparison with a new high-performance liquid chromatographic assay with electrochemical detection.气相色谱-质谱法测定血浆中氯丙嗪及其与新型高效液相色谱电化学检测法的比较
J Chromatogr. 1982 Nov 12;232(2):275-82.
7
Gas-chromatographic methods for the study of chlorpromazine and some of its metabolities in human plasma.用于研究人体血浆中氯丙嗪及其某些代谢产物的气相色谱法。
Psychopharmacol Commun. 1976;2(1):1-15.
8
Determination of nanogram quantities of chlorpromazine and some of its metabolites in plasma using gas-liquid chromatography with an electron capture detector.使用带有电子捕获检测器的气液色谱法测定血浆中纳克量的氯丙嗪及其一些代谢物。
Anal Chem. 1968 Jul;40(8):1251-5. doi: 10.1021/ac60264a031.
9
Chlorpromazine analysis by gas chromatography with an electron-capture detector.采用带有电子捕获检测器的气相色谱法分析氯丙嗪。
Adv Biochem Psychopharmacol. 1974;9(0):335-45.
10
Artifactual contamination of control serum extracts in gas chromatographic analyses for chlorpromazine.气相色谱法分析氯丙嗪时对照血清提取物的人为污染
Clin Chem. 1972 Mar;18(3):317-8.