血清中氯丙嗪的气相色谱分析方法改进
Improved gas chromatographic analysis of chlorpromazine in blood serum.
作者信息
Davis C M, Meyer C J, Fenimore D C
出版信息
Clin Chim Acta. 1977 Jul 1;78(1):71-7. doi: 10.1016/0009-8981(77)90338-2.
PMID:884850
Abstract
Reliable determinations of chlorpromazine levels in blood serum samples obtained from patients were accomplished by electron capture gas chromatography. By using modifications of the procedure to insure stability of the sample, minimal losses during sample preparation and gas chromatography, and by selecting appropriate operating parameters of the electron capture detector, excellent agreement was obtained in replicate analyses with a limit of sensitivity of 1 ng/ml in 1 ml of plasma.
摘要
通过电子捕获气相色谱法可对从患者身上采集的血清样本中的氯丙嗪水平进行可靠测定。通过对该程序进行改进以确保样本的稳定性、样本制备和气相色谱过程中的最小损失，并选择电子捕获检测器的适当操作参数，在重复分析中获得了极佳的一致性，血浆中1毫升的检测灵敏度极限为1纳克/毫升。
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