Bhartiya D, Bajpai V K
Electron Microscopy Section, Central Drug Research Institute, Chattar Manzil Palace, Lucknow, India.
Reprod Fertil Dev. 1995;7(5):1199-207. doi: 10.1071/rd9951199.
The present study was undertaken to correlate the surface topography of endometrium with altered concentrations of circulating steroids during different phases of the artificially-induced menstrual cycle. Scanning electron microscopy demonstrated that oestradiol during the oestrogenic phase induces an increase in the number of ciliated cells and the size of microvilli; by contrast, progesterone, in addition to inducing secretory activity in non-ciliated cells, had a negative effect on oestradiol-dependent morphological characteristics of ciliated cells, causing a reduction in cell number and deciliation, and inducing drooping of cilia during the progestogenic phase of the artificially-induced menstrual cycle. In addition, surface and glandular epithelial cells both actively participate in restoration of the endometrial surface during the menstrual phase, an event which parallels endometrial shedding.
本研究旨在关联人工诱导月经周期不同阶段子宫内膜的表面形貌与循环类固醇浓度的变化。扫描电子显微镜显示，雌激素期的雌二醇会使纤毛细胞数量增加且微绒毛尺寸增大；相比之下，孕酮除了诱导非纤毛细胞的分泌活动外，对纤毛细胞依赖雌二醇的形态特征有负面影响，导致人工诱导月经周期的孕激素期纤毛细胞数量减少、脱纤毛，并诱导纤毛下垂。此外，表面上皮细胞和腺上皮细胞在月经期均积极参与子宫内膜表面的修复，这一过程与子宫内膜脱落同步。
