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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Prakash N J, Schechter P J, Giroux E, Sjoerdsma A

Clin Exp Pharmacol Physiol. 1977 Jan-Feb;4(1):17-26. doi: 10.1111/j.1440-1681.1977.tb02373.x.

Gavage of rats with beta-aryl derivatives of alpha-mercaptoacrylic acid resulted in pronounced and sustained elevation of serum zinc concentration. Greater than ten-fold increases above normal zinc levels were attained 2-8 h after doses of 50 mg/kg of the phenyl and furan derivatives. 2. These compounds were rapidly absorbed from the rat gastrointestinal tract and could be detected in serum for several days after a single dose. The return of serum zinc concentration to the normal level paralleled clearance of the mercaptoacrylic acid from plasma. 3. Close to 100% of the zinc and of the alpha-mercapto-beta-(2-furan)acrylic acid (MFA) in serum 4 h after administration of the compound were bound to serum macromolecules. 4. MFA decreased excretion of endogenous zinc; it altered neither the gastrointestinal absorption of zinc nor serum concentrations of copper, albumin and total protein. 5. These compounds appear to mobilize zinc from tissue stores and retard zinc clearance from plasma.

用α-巯基丙烯酸的β-芳基衍生物对大鼠进行灌胃，导致血清锌浓度显著且持续升高。给予50mg/kg的苯基和呋喃衍生物后2至8小时，锌水平比正常水平升高了十倍以上。
这些化合物能迅速从大鼠胃肠道吸收，单次给药后数天内可在血清中检测到。血清锌浓度恢复到正常水平与巯基丙烯酸从血浆中的清除同步。
给药后4小时，血清中近100%的锌和α-巯基-β-(2-呋喃)丙烯酸（MFA）与血清大分子结合。
MFA减少了内源性锌的排泄；它既不改变锌的胃肠道吸收，也不改变铜、白蛋白和总蛋白的血清浓度。
这些化合物似乎从组织储存中动员锌，并延缓锌从血浆中的清除。

Prakash N J, Schechter P J, Giroux E, Sjoerdsma A

Clin Exp Pharmacol Physiol. 1977 Jan-Feb;4(1):17-26. doi: 10.1111/j.1440-1681.1977.tb02373.x.

Gavage of rats with beta-aryl derivatives of alpha-mercaptoacrylic acid resulted in pronounced and sustained elevation of serum zinc concentration. Greater than ten-fold increases above normal zinc levels were attained 2-8 h after doses of 50 mg/kg of the phenyl and furan derivatives. 2. These compounds were rapidly absorbed from the rat gastrointestinal tract and could be detected in serum for several days after a single dose. The return of serum zinc concentration to the normal level paralleled clearance of the mercaptoacrylic acid from plasma. 3. Close to 100% of the zinc and of the alpha-mercapto-beta-(2-furan)acrylic acid (MFA) in serum 4 h after administration of the compound were bound to serum macromolecules. 4. MFA decreased excretion of endogenous zinc; it altered neither the gastrointestinal absorption of zinc nor serum concentrations of copper, albumin and total protein. 5. These compounds appear to mobilize zinc from tissue stores and retard zinc clearance from plasma.

用α-巯基丙烯酸的β-芳基衍生物对大鼠进行灌胃，导致血清锌浓度显著且持续升高。给予50mg/kg的苯基和呋喃衍生物后2至8小时，锌水平比正常水平升高了十倍以上。
这些化合物能迅速从大鼠胃肠道吸收，单次给药后数天内可在血清中检测到。血清锌浓度恢复到正常水平与巯基丙烯酸从血浆中的清除同步。
给药后4小时，血清中近100%的锌和α-巯基-β-(2-呋喃)丙烯酸（MFA）与血清大分子结合。
MFA减少了内源性锌的排泄；它既不改变锌的胃肠道吸收，也不改变铜、白蛋白和总蛋白的血清浓度。
这些化合物似乎从组织储存中动员锌，并延缓锌从血浆中的清除。