对环硫噻吨、香豆霉素和新生霉素耐药的金黄色葡萄球菌菌株中的GyrB突变。
GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.
作者信息
Stieger M, Angehrn P, Wohlgensinger B, Gmünder H
机构信息
F. Hoffmann-La Roche, Basel, Switzerland.
出版信息
Antimicrob Agents Chemother. 1996 Apr;40(4):1060-2. doi: 10.1128/AAC.40.4.1060.
Abstract
The sequence of the gyrase B subunit gene from Staphylococcus aureus strains resistant to the gyrase B subunit inhibitors cyclothialidine, coumermycin, and novobiocin has been determined. The residues altered in the resistant gyrase B subunits map to the ATP-binding region, suggesting that the drugs inhibit ATP binding and hydrolysis. The pattern of cross-resistances indicates that the detailed binding mode of the compounds differs.
摘要
已确定对回旋酶B亚基抑制剂噻环硫肽、香豆霉素和新生霉素耐药的金黄色葡萄球菌菌株的回旋酶B亚基基因序列。耐药的回旋酶B亚基中发生改变的残基定位于ATP结合区域，这表明这些药物抑制ATP结合和水解。交叉耐药模式表明这些化合物的详细结合模式有所不同。
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