Levy D, Bluzat A, Seigneuret M, Rigaud J L
Laboratoire de Biophysique Cellulaire, CNRS-URA 526, Université Paris 7, France.
Biochem Pharmacol. 1995 Dec 22;50(12):2105-7. doi: 10.1016/0006-2952(95)02045-4.
Fusafungine is a peptide antibiotic mixture composed of several enniatins and active against Gram-positive bacteria. Ionophoric properties of fusafungine have been studied in liposomes by measuring protoncation exchange by both fluorescence and 31P-nuclear magnetic resonance (NMR) and have been compared to those of its constituent enniatin peptides. Fusafungine, as well as enniatins, transport cations through a mobile carrier mechanism selective for K+ vs. Na+ and involving two antibiotic molecules. The transport efficiencies of the various enniatins appear to be related to their hydrophobicity, in agreement with a previously proposed "sandwich" transport model. The ionophoric properties of crude fusafungine may be involved in its antibiotic action and its local therapeutic properties.
夫沙芬净是一种由多种恩镰孢菌素组成的肽类抗生素混合物，对革兰氏阳性菌具有活性。通过荧光和31P核磁共振（NMR）测量质子阳离子交换，在脂质体中研究了夫沙芬净的离子载体特性，并将其与其组成的恩镰孢菌素肽的离子载体特性进行了比较。夫沙芬净以及恩镰孢菌素通过对K+与Na+具有选择性的移动载体机制运输阳离子，该机制涉及两个抗生素分子。各种恩镰孢菌素的运输效率似乎与其疏水性有关，这与先前提出的“三明治”运输模型一致。粗制夫沙芬净的离子载体特性可能涉及其抗生素作用和局部治疗特性。
