二氧化碳毫瓦激光对大鼠神经瘤形成的影响。
Effect of the CO2 milliwatt laser on neuroma formation in rats.
作者信息
Kuzbari R, Liegl C, Neumayer C, Moser H, Burggasser G, Holle J, Gruber H, Happak W
机构信息
Department of Plastic Surgery, Wilhelminen Hospital, Vienna, Austria.
出版信息
Lasers Surg Med. 1996;18(1):81-5. doi: 10.1002/(SICI)1096-9101(1996)18:1<81::AID-LSM10>3.0.CO;2-E.
BACKGROUND AND OBJECTIVE
The purpose of this study was to determine whether the milliwatt laser can suppress neuroma formation at the end of a divided nerve.
STUDY DESIGN/MATERIALS AND METHODS: The peripheral nerves of eight rats were transected with microscissors and the cross-sectional area of their proximal ends was irradiated using the CO2 milliwatt laser. The power ranges used were similar to those applied to weld neural tissue.
RESULTS
None of the eight irradiated nerve ends formed a neuromatous bulb and only one of them regenerated into the surrounding tissues. Histologically, these nerve ends did not show the disorganized picture of classic neuromas. On morphometric measurements, they contained less connective tissue than the control nerve ends (P < 0.001) and their nerve fibers were larger in diameter (P < 0.001) and better myelinated (P < 0.001).
CONCLUSION
These findings in rats show that the CO2 milliwatt laser has the ability to suppress neuroma formation at the end of a divided nerve.
背景与目的
本研究旨在确定毫瓦激光是否能抑制离断神经末端的神经瘤形成。
研究设计/材料与方法：用显微剪刀切断8只大鼠的外周神经，并用二氧化碳毫瓦激光照射其近端横截面。所用功率范围与用于焊接神经组织的功率范围相似。
结果
8个接受照射的神经末端均未形成神经瘤样球状物，其中只有1个再生至周围组织。组织学上，这些神经末端未呈现经典神经瘤的紊乱图像。形态计量学测量显示，它们所含结缔组织比对照神经末端少（P < 0.001），其神经纤维直径更大（P < 0.001）且髓鞘化更好（P < 0.001）。
结论
大鼠的这些研究结果表明，二氧化碳毫瓦激光具有抑制离断神经末端神经瘤形成的能力。
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