Kuszyk B S, Venbrux A C, Samphilipo M A, Magee C A, Olson J L, Osterman F A
Department of Cardiovascular and Interventional Radiology, Johns Hopkins Hospital, Baltimore, MD 21287, USA.
J Vasc Interv Radiol. 1995 Nov-Dec;6(6):895-902. doi: 10.1016/s1051-0443(95)71209-x.
To evaluate the histopathologic effects of the Tempo-filter, a temporary caval filter, on the caval wall and determine the feasibility of deployment and removal of the device in swine.
Filters were placed in the infrarenal inferior vena cava of 11 swine. The tethering catheter was sutured in a subcutaneous pocket near the puncture site. The original tethering catheter used in humans and a stiffer catheter designed to prevent migration in swine were evaluated. Postplacement, mid-study, and preexplant vena cavography procedures were performed. Four swine underwent in situ dissection at 3-10 weeks. Filters were removed from seven animals just before they were killed at 1-6 weeks.
All filters were successfully placed. All seven filters were successfully removed at up to 6 weeks after placement. Cephalic migration of more than 1 cm was observed in 10 of 11 swine (100% of original catheters, 83% of stiff catheters). Other complications were more common with stiffer tethering catheters, including caval stenosis in 40% of original catheters and 100% of stiff catheters, filter cone thrombus in 0% and 67%, tethering catheter thrombus in 20% and 83%, pulmonary embolism in 0% and 50%, and death in 0% and 17%, respectively. There was mild vessel wall damage in the vena cava.
Placement of the Tempofilter and removal at up to 6 weeks after placement is feasible.
评估临时腔静脉滤器Tempo-filter对腔静脉壁的组织病理学影响，并确定该装置在猪体内展开和取出的可行性。
将滤器置于11头猪的肾下下腔静脉中。将系留导管缝合在穿刺部位附近的皮下袋中。对人类使用的原始系留导管和为防止在猪体内移位而设计的更硬导管进行了评估。放置后、研究中期和取出前进行了腔静脉造影检查。4头猪在3至10周时进行了原位解剖。7只动物在1至6周处死前取出了滤器。
所有滤器均成功放置。所有7个滤器在放置后长达6周时均成功取出。11头猪中有10头（原始导管的100%，硬导管的83%）观察到头端移位超过1 cm。其他并发症在更硬的系留导管中更常见，包括原始导管的40%和硬导管的100%出现腔静脉狭窄，滤器圆锥血栓分别为0%和67%，系留导管血栓分别为20%和83%，肺栓塞分别为0%和50%，死亡分别为0%和17%。腔静脉有轻度血管壁损伤。
放置Tempofilter并在放置后长达6周取出是可行的。
