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海马的缺血性病变及其与阿蒙角硬化的关系。两例神经病理学研究及与血管解剖的比较。

Ischemic lesions of the hippocampus and their relation to Ammon's horn sclerosis. A neuropathological study of two cases and a comparison to the vascular anatomy.

作者信息

DeReuck J, Van Kerckvoorde L, De Coster W, vander Eecken H

出版信息

J Neurol. 1979 May 2;220(3):157-68. doi: 10.1007/BF00705534.

DOI:10.1007/BF00705534
PMID:88508
Abstract

Two adult brains with small ischemic lesions in the hippocampus, due to impairment of the supply from the posterior cerebral artery, are presented. The first case corresponds to what is described in the literature as "incisural sclerosis" and shows no difference in vulnerability between the Sommer and the Spielmeyer sector. In the second case the hippocampal lesion is due to an embolic occlusion of the posterior cerebral artery and consists of selective necrosis of the subiculum, the Sommer sector and part of the endfolium of the pyramidal layer, the Spielmeyer sector remaining noninfarcted. The postmortem angiograms of 12l hippocampi of adults, as well as full term born and premature infants, show that the h1 and h2 sectors and part of the h3 sector of the hippocampus are supplied by the same "sulcus" arteries. Although there is a selective vulnerability to ischemia in some sectors of the hippocampus, which is typical for Ammon's horn sclerosis, this cannot be explained by a difference of arterial supply or by compression of arteries during the process of birth.

摘要

本文展示了两例成人大脑,其海马区存在小的缺血性病变,病因是大脑后动脉供血受损。第一例符合文献中描述的“切迹硬化”,在索默(Sommer)区和施皮尔曼(Spielmeyer)区之间未显示出易损性差异。第二例海马区病变是由于大脑后动脉栓塞性闭塞所致,包括海马下脚、索默区以及锥体细胞层终板部分的选择性坏死,而施皮尔曼区未发生梗死。对121例成人以及足月出生和早产婴儿的海马进行的尸检血管造影显示,海马的h1和h2区以及部分h3区由相同的“沟”动脉供血。尽管海马的某些区域对缺血存在选择性易损性,这是海马角硬化的典型特征,但这无法通过动脉供血差异或出生过程中动脉受压来解释。

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本文引用的文献

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Compression of brain arteries as pathogenetic factor for tissue necroses and their areas of predilection.脑动脉受压作为组织坏死及其好发部位的致病因素。
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