Gille G, Sigler K
Institute of Botany, Bonn, Germany.
Folia Microbiol (Praha). 1995;40(2):131-52. doi: 10.1007/BF02815413.
The review deals with the effects of reactive oxygen species, both radical and nonradical (e.g. hydrogen peroxide), on cells and organisms. The chemical and biochemical aspects include description of individual reactive oxygen species, chemical reactions giving rise to them, their interconversions and interactions with metals (Fe2+, Cu2+, Cu+) and other substances (scavengers, antioxidants). The biological aspects concern the specific features and locations of cellular enzyme systems involved in radical production and/or removal. Major harmful effects of the species on the molecular (protein oxidation, lipid peroxidation, damage to DNA) and cellular level (effect on signal transduction, on cell membrane functions and on gene expression) are surveyed. Methods whereby cells and organisms cope with the onslaught of these reactive species are reviewed as well as implications for plant, animal and human health.
本综述探讨了活性氧物种（包括自由基和非自由基，如过氧化氢）对细胞和生物体的影响。化学和生物化学方面包括对单个活性氧物种的描述、产生它们的化学反应、它们的相互转化以及与金属（Fe2+、Cu2+、Cu+）和其他物质（清除剂、抗氧化剂）的相互作用。生物学方面涉及参与自由基产生和/或清除的细胞酶系统的具体特征和位置。综述了这些物种在分子水平（蛋白质氧化、脂质过氧化、DNA损伤）和细胞水平（对信号转导、细胞膜功能和基因表达的影响）上的主要有害影响。还综述了细胞和生物体应对这些活性物种攻击的方法以及对植物、动物和人类健康的影响。
