阿奇霉素在脑组织、脑脊液和眼房水中的分布。
Distribution of azithromycin into brain tissue, cerebrospinal fluid, and aqueous humor of the eye.
作者信息
Jaruratanasirikul S, Hortiwakul R, Tantisarasart T, Phuenpathom N, Tussanasunthornwong S
机构信息
Department of Medicine, Prince of Songkla University, Hat Yai, Songkla, Thailand.
出版信息
Antimicrob Agents Chemother. 1996 Mar;40(3):825-6. doi: 10.1128/AAC.40.3.825.
To measure the concentrations of azithromycin in the central nervous system, 20 patients with brain tumors (group I) received a single 500-mg oral dose of azithromycin either 24, 48, 72, or 96 h prior to the tumor removal operation and 10 patients with cataracts undergoing surgery (group II) and 7 patients scheduled to undergo lumbar puncture (group III) received the same dose of azithromycin 24 h prior to the operation or procedure. Serum from all patients, brain tissue from group I, aqueous humor from group II, and cerebrospinal fluid from group III were assayed for azithromycin concentration. The mean concentrations of azithromycin in brain tissue 24, 48, 72, and 96 h after administration were 2.63 +/- 2.58, 3.64 +/- 3.81, 0.74 +/- 0.37, and 0.41 micrograms/g, respectively. In contrast, the concentrations of azithromycin in cerebrospinal fluid and aqueous humor of the eye were very low or undetectable. Therefore, these data show that azithromycin appears to be widely distributed into brain tissue but not into cerebrospinal fluid or aqueous humor of the eye.
为测定阿奇霉素在中枢神经系统中的浓度，20例脑肿瘤患者（I组）在肿瘤切除手术前24、48、72或96小时口服单次500毫克阿奇霉素，10例接受白内障手术的患者（II组）和7例计划接受腰椎穿刺的患者（III组）在手术或操作前24小时接受相同剂量的阿奇霉素。对所有患者的血清、I组的脑组织、II组的房水和III组的脑脊液进行阿奇霉素浓度测定。给药后24、48、72和96小时脑组织中阿奇霉素的平均浓度分别为2.63±2.58、3.64±3.81、0.74±0.37和0.41微克/克。相比之下，脑脊液和眼房水中阿奇霉素的浓度非常低或无法检测到。因此，这些数据表明阿奇霉素似乎广泛分布于脑组织中，但未分布于脑脊液或眼房水中。
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