阿奇霉素，一种对弓形虫具有强效活性的大环内酯类抗生素。
Azithromycin, a macrolide antibiotic with potent activity against Toxoplasma gondii.
作者信息
Araujo F G, Guptill D R, Remington J S
机构信息
Research Institute, Palo Alto Medical Foundation, California 94301.
出版信息
Antimicrob Agents Chemother. 1988 May;32(5):755-7. doi: 10.1128/AAC.32.5.755.
Abstract
Doses of 200 mg of azithromycin per kg (body weight) administered by the oral route daily for 10 days completely protected mice against death caused by intraperitoneal infection with Toxoplasma gondii. The same treatment regimen also protected 80% of mice infected intracerebrally, which suggests that azithromycin attains active concentrations in the inflamed central nervous system.
摘要
以每千克（体重）200毫克阿奇霉素经口服途径每日给药，持续10天，可使小鼠完全免受腹腔感染刚地弓形虫所致的死亡。相同的治疗方案还保护了80%脑内感染的小鼠，这表明阿奇霉素在炎症的中枢神经系统中能达到有效浓度。
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