Blehar M C
National Institute of Mental Health, NIH, Rockville, MD 20857, USA.
Psychopharmacol Bull. 1995;31(4):687-91.
This article discusses the utility and treatment implications of a focus on gender-related variables in the study of the mood and anxiety disorders. Three clinical areas are considered: (1) Mood and anxiety disorders during female reproductive transitions; (2) gender differences in pathogenesis and pathopsysiology; and (3) gender differences in clinical phenomenology and course. Gender analysis is viewed as useful in specifying variability in treatment response, especially in regard to the menstrual cycle, pregnancy, the postpartum period, and menopause; and in defining clinical covariates modifying treatment course. A psychobiological approach to mood and anxiety disorders is seen as critical in this regard.
本文讨论了在情绪和焦虑障碍研究中关注性别相关变量的实用性及治疗意义。考虑了三个临床领域：（1）女性生殖过渡期间的情绪和焦虑障碍；（2）发病机制和病理生理学中的性别差异；以及（3）临床现象学和病程中的性别差异。性别分析被认为有助于明确治疗反应的变异性，特别是在月经周期、怀孕、产后和更年期方面；以及在确定影响治疗过程的临床协变量方面。在这方面，采用心理生物学方法研究情绪和焦虑障碍至关重要。
