Kim H M, Han S B, Chang W I, Hyun B H, Oh G T, Ahn C J, Cha Y N
Korea Research Institute of Bioscience and Biotechnology, Taejon City.
J Toxicol Sci. 1996 Feb;21(1):41-5. doi: 10.2131/jts.21.41.
Effect of antioxidants on humoral immune responses, such as butylated hydroxytoluene (BHT), n-propyl gallate (PG) and dimethyl sulfoxide (DMSO) is suppression in vitro antibody production. These antioxidants all inhibited T-dependent B cell response, not T-independent and polyclonal B cell response. These data suggest that antioxidants suppress humoral immunity by suppression of regulation of T cells or action of macrophages on B cells, not by direct suppression of B cells. The other possible explanation for antioxidant action is the lack of T-B cell contact required for the triggering of the B cell response with T-dependent antigens.
抗氧化剂如丁基羟基甲苯（BHT）、没食子酸丙酯（PG）和二甲基亚砜（DMSO）对体液免疫反应的影响是抑制体外抗体产生。这些抗氧化剂均抑制T细胞依赖性B细胞反应，而非T细胞非依赖性和多克隆B细胞反应。这些数据表明，抗氧化剂通过抑制T细胞调节或巨噬细胞对B细胞的作用来抑制体液免疫，而非直接抑制B细胞。抗氧化剂作用的另一种可能解释是缺乏用T细胞依赖性抗原触发B细胞反应所需的T - B细胞接触。
