Reunala T, Koskimies A I, Björksten F, Jänne J, Lassus A
Fertil Steril. 1977 Aug;28(8):832-5. doi: 10.1016/s0015-0282(16)42736-6.
Two women with allergy to human seminal plasma are described. Both patients had generalized and local allergic symptoms, i.e., hypotension, asthmatic dyspnea, urticaria, and vaginal swelling, beginning within a few minutes of intercourse. The antigen causing the reaction in these patients was common to all seminal plasmas examined. Most of the antigenic activity was shown to be present in one protein band detected by acrylamide gel electrophoresis. The seminal plasma reaction was mediated through an immunoglobulin E (IgE) antibody. Passive transfer of the hypersensitivity with the serum of both patients was successful, and the radioallergosorbent test showed that the serum of the first patient contained IgE specific to seminal plasma.
本文描述了两名对人类精浆过敏的女性。两名患者均出现全身和局部过敏症状，即性交后几分钟内出现低血压、哮喘性呼吸困难、荨麻疹和阴道肿胀。在所有检测的精浆中，引起这些患者反应的抗原是相同的。通过丙烯酰胺凝胶电泳检测发现，大部分抗原活性存在于一条蛋白带中。精浆反应是由免疫球蛋白E（IgE）抗体介导的。用两名患者的血清成功进行了超敏反应的被动转移，放射变应原吸附试验表明，第一名患者的血清中含有精浆特异性IgE。
