Raad I, Hachem R, Leeds N, Sawaya R, Salem Z, Atweh S
Department of Medical Specialties, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Clin Infect Dis. 1996 Mar;22(3):572-4. doi: 10.1093/clinids/22.3.572.
We describe a patient with acute lymphocytic leukemia and multidrug-resistant tuberculosis of the brain and spinal cord. Despite treatment with six antituberculous drugs and a steroid medication for 11 months, there was no appreciable clinical or radiological improvement in the patient's condition. Within 5 months of initiating adjunctive therapy with IFN-gamma and granulocyte colony stimulating factors, substantial neurological and radiological improvement was noted. Therapy with IFN-gamma was continued for 12 months, resulting in complete resolution of the lesions in the brain and spinal cord.
我们描述了一名患有急性淋巴细胞白血病以及脑和脊髓耐多药结核病的患者。尽管使用六种抗结核药物和一种类固醇药物治疗了11个月，但患者的病情在临床和影像学上均无明显改善。在开始使用γ干扰素和粒细胞集落刺激因子进行辅助治疗的5个月内，观察到神经功能和影像学有显著改善。γ干扰素治疗持续了12个月，导致脑和脊髓病变完全消退。
