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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Pagliaro P, Dalla Valle R, Gattullo D, Merletti A, Marsh N A

Dipartimento di Anatomia e Fisiologia Umana, Università di Torino, Italy.

Gen Pharmacol. 1996 Jun;27(4):695-9. doi: 10.1016/0306-3623(95)02042-x.

The effect of nitric oxide (NO) inhibition on heart rate was studied in anaesthetized vagotomized dogs. 2. The effect of changes of baroreceptor stimulation was prevented using an arterial pressure reservoir. 3. After NO-inhibitor (Nitro-L-arginine), heart rate decreased by 8% in spite of an unchanged pressure. 4. When upstream pressure was increased by constriction of the descending aorta, heart rate decreased by 4% before and after inhibition. Owing to the vagotomy this decrease was attributed to a sympathetic tone reduction following baroreceptor stimulation. 5. The results show that NO-inhibition reduces heart rate independently of an increased baroreceptor stimulation and does not reduce the basal sympathetic control on the sinus-atrial node.

在麻醉的迷走神经切断犬中研究了一氧化氮（NO）抑制对心率的影响。2. 使用动脉压力贮器防止压力感受器刺激变化的影响。3. 给予NO抑制剂（硝基-L-精氨酸）后，尽管压力未变，心率仍下降了8%。4. 当下行主动脉收缩使上游压力升高时，抑制前后心率均下降4%。由于迷走神经切断，这种下降归因于压力感受器刺激后交感神经张力降低。5. 结果表明，NO抑制可独立于压力感受器刺激增加而降低心率，且不降低对窦房结的基础交感神经控制。

Pagliaro P, Dalla Valle R, Gattullo D, Merletti A, Marsh N A

Dipartimento di Anatomia e Fisiologia Umana, Università di Torino, Italy.

Gen Pharmacol. 1996 Jun;27(4):695-9. doi: 10.1016/0306-3623(95)02042-x.

The effect of nitric oxide (NO) inhibition on heart rate was studied in anaesthetized vagotomized dogs. 2. The effect of changes of baroreceptor stimulation was prevented using an arterial pressure reservoir. 3. After NO-inhibitor (Nitro-L-arginine), heart rate decreased by 8% in spite of an unchanged pressure. 4. When upstream pressure was increased by constriction of the descending aorta, heart rate decreased by 4% before and after inhibition. Owing to the vagotomy this decrease was attributed to a sympathetic tone reduction following baroreceptor stimulation. 5. The results show that NO-inhibition reduces heart rate independently of an increased baroreceptor stimulation and does not reduce the basal sympathetic control on the sinus-atrial node.

在麻醉的迷走神经切断犬中研究了一氧化氮（NO）抑制对心率的影响。2. 使用动脉压力贮器防止压力感受器刺激变化的影响。3. 给予NO抑制剂（硝基-L-精氨酸）后，尽管压力未变，心率仍下降了8%。4. 当下行主动脉收缩使上游压力升高时，抑制前后心率均下降4%。由于迷走神经切断，这种下降归因于压力感受器刺激后交感神经张力降低。5. 结果表明，NO抑制可独立于压力感受器刺激增加而降低心率，且不降低对窦房结的基础交感神经控制。