分解代谢状态下获得性生长激素抵抗
Acquired growth hormone resistance in catabolic states.
作者信息
Jenkins R C, Ross R J
机构信息
University of Sheffield, Clinical Sciences Centre, Northern General Hospital.
出版信息
Baillieres Clin Endocrinol Metab. 1996 Jul;10(3):411-9. doi: 10.1016/s0950-351x(96)80545-3.
PMID:8853448
Abstract
Catabolic patients are resistant to the actions of GH. This resistance is probably multifactorial in origin. It is likely that both the fasting state and circulating factors, possibly cytokines, are aetiological. Resistance or insensitivity is characterized by raised GH levels, low IGF-I levels and a reduced anabolic response to GH.
摘要
分解代谢患者对生长激素（GH）的作用具有抵抗性。这种抵抗可能源于多种因素。禁食状态和循环因子（可能是细胞因子）都可能是病因。抵抗或不敏感的特征是GH水平升高、胰岛素样生长因子-I（IGF-I）水平降低以及对GH的合成代谢反应减弱。
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