Pryor S C, Fascher E
Old Westbury Neuroscience Research Institute, State University of New York 11568, USA.
Acta Biol Hung. 1995;46(2-4):329-40.
The effects of morphine, Met-enkephalin, and its synthetic analogue DAMA on the hemocytes of Culex pipiens mosquitoes were examined in vitro. Morphine caused the cells to round up and decrease in area. Met-enkephalin caused the cells to become ameboid and increase in area. This effect was accentuated with the addition of the neutral endopeptidase blocker phosphoramidon. DAMA caused a similar but greater enhancement of immune activation which was blocked by the opiate antagonist, naloxone. These results were similar to those seen in other invertebrate hemocytes.
在体外研究了吗啡、甲硫氨酸脑啡肽及其合成类似物DAMA对致倦库蚊血细胞的影响。吗啡使细胞变圆且面积减小。甲硫氨酸脑啡肽使细胞变成阿米巴样且面积增大。添加中性内肽酶阻断剂磷酰胺素可增强这种作用。DAMA引起类似但更强的免疫激活增强，这被阿片拮抗剂纳洛酮阻断。这些结果与在其他无脊椎动物血细胞中观察到的结果相似。
