Bakin J S, Weinberger N M
Department of Psychobiology, University of California, Irvine 92717-3800, USA.
Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11219-24. doi: 10.1073/pnas.93.20.11219.
Auditory cortical receptive field plasticity produced during behavioral learning may be considered to constitute "physiological memory" because it has major characteristics of behavioral memory: associativity, specificity, rapid acquisition, and long-term retention. To investigate basal forebrain mechanisms in receptive field plasticity, we paired a tone with stimulation of the nucleus basalis, the main subcortical source of cortical acetylcholine, in the adult guinea pig. Nucleus basalis stimulation produced electroencephalogram desynchronization that was blocked by systemic and cortical atropine. Paired tone/nucleus basalis stimulation, but not unpaired stimulation, induced receptive field plasticity similar to that produced by behavioral learning. Thus paired activation of the nucleus basalis is sufficient to induce receptive field plasticity, possibly via cholinergic actions in the cortex.
在行为学习过程中产生的听觉皮层感受野可塑性可被认为构成了“生理记忆”，因为它具有行为记忆的主要特征：关联性、特异性、快速习得和长期保持。为了研究感受野可塑性中的基底前脑机制，我们在成年豚鼠中将一个音调与基底核（皮层乙酰胆碱的主要皮层下来源）的刺激配对。基底核刺激产生的脑电图去同步化被全身和皮层阿托品阻断。音调/基底核配对刺激而非非配对刺激诱导出了与行为学习产生的感受野可塑性相似的结果。因此，基底核的配对激活足以诱导感受野可塑性，可能是通过皮层中的胆碱能作用实现的。
