Bjordahl T S, Dimyan M A, Weinberger N M
Department of Psychobiology, Center for the Neurobiology of Learning and Memory, University of California, Irvine 92697-3800, USA.
Behav Neurosci. 1998 Jun;112(3):467-79. doi: 10.1037//0735-7044.112.3.467.
Learning induces neuronal receptive field (RF) plasticity in primary auditory cortex. This plasticity constitutes physiological memory as it is associative, highly specific, discriminative, develops rapidly, and is retained indefinitely. This study examined whether pairing a tone with activation of the nucleus basalis could induce RF plasticity in the waking guinea pig and, if so, whether it could be retained for 24 hr. Subjects received 40 trials of a single frequency paired with electrical stimulation of the nucleus basalis (NB) at tone offset. The physiological effectiveness of NB stimulation was assessed later while subjects were anesthetized with urethane by noting whether stimulation produced cortical desynchronization. Subjects in which NB stimulation was effective did develop RF plasticity and this was retained for 24 hr. Thus, activation of the NB during normal learning may be sufficient to induce enduring physiological memory in auditory cortex.
学习可诱导初级听觉皮层中神经元感受野（RF）的可塑性。这种可塑性构成了生理记忆，因为它具有关联性、高度特异性、辨别性，发展迅速且能无限期保留。本研究考察了将音调与基底核激活配对是否能在清醒的豚鼠中诱导RF可塑性，如果可以，这种可塑性是否能保留24小时。实验对象接受了40次单一频率的试验，在音调结束时将其与基底核（NB）的电刺激配对。随后在实验对象用乌拉坦麻醉时，通过观察刺激是否产生皮层去同步化来评估NB刺激的生理有效性。NB刺激有效的实验对象确实产生了RF可塑性，并且这种可塑性保留了24小时。因此，在正常学习过程中激活NB可能足以在听觉皮层中诱导持久的生理记忆。
